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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: J Med Chem. 2011 Aug 17;54(18):6254–6276. doi: 10.1021/jm200570p

Scheme 3.

Scheme 3

Synthesis of (E)-styryl benzyl sulfones from phenacy benzyl sulfonesa

a Reagents and conditions: (a) NaOH, MeOH, rt, 2 h; (b) 30% H2O2, ACOH, rt, 24 h; (c) NaBH4, tetrahydrofuran, 0 °C, 1 h; (d) p-toluenesulfonic acid, toluene, 2–4 h.