. Author manuscript; available in PMC: 2015 Jul 15.

Published in final edited form as: J Med Chem. 2011 Aug 17;54(18):6254–6276. doi: 10.1021/jm200570p

Table 5.

Evaluation of 8p and 28 against a panel of Multidrug-resistance Human Tumor Cell lines

Cell Line	Tumor Type	IC₅₀ (μM)
Cell Line	Tumor Type	8p	28
MES-SA	Sarcoma	0.004	0.1
MES-SA/DX5^a	Resistant Sarcoma	0.004	0.1
CEM	Leukemic	0.01	0.1
CEM/C2^a	Resistant Leukemic	0.01	0.05
2008	Ovarian	0.003	0.15
2008/17/4	Resistant Ovarian	0.003	0.1

These cell lines constitute multidrug-resistance cell lines and show up-regulation of MDR and in the case of CEM/C2, additional mutations in the Topo-2 gene.^19,20