Table 2.
Hazard ratios (HR) and 95% confidence intervals (CI) for total, invasive, and in situ breast cancer associated with lifetime exposure
| Total Breast Cancer | Invasive Breast Cancer3 | In situ Breast Cancer3 | ||||||
|---|---|---|---|---|---|---|---|---|
| Exposure1 Prevalence | Cases n = 1,966 |
HR2 | Cases n = 1,421 |
HR2 | Cases n = 531 |
HR2 | ||
| No. | (%) | |||||||
|
Acids | ||||||||
| Ever Use | 1554 | (3) | 75 | 1.1 (0.9, 1.4) | 53 | 1.1 (0.8, 1.4) | 22 | 1.2 (0.8, 1.9) |
| Never Use | 46027 | (97) | 1,890 | 1.0 | 1,367 | 1.0 | 509 | 1.0 |
|
Dyes or inks | ||||||||
| Ever Use | 2304 | (5) | 98 | 1.1 (0.9, 1.3) | 80 | 1.2 (1.0, 1.6) | 18 | 0.7 (0.4, 1.2) |
| Never Use | 45299 | (95) | 1,868 | 1.0 | 1,341 | 1.0 | 513 | 1.0 |
|
Gasoline or other petroleum products | ||||||||
| Ever Use | 1998 | (4) | 66 | 0.8 (0.7, 1.1) | 54 | 1.0 (0.7, 1.3) | 11 | 0.5 (0.2, 0.9) |
| Never Use | 45613 | (96) | 1,899 | 1.0 | 1,366 | 1.0 | 520 | 1.0 |
|
Glues or adhesives | ||||||||
| Ever Use | 3626 | (8) | 143 | 0.9 (0.8, 1.1) | 105 | 0.9 (0.8, 1.1) | 37 | 0.9 (0.6, 1.3) |
| Never Use | 43986 | (92) | 1,823 | 1.0 | 1,316 | 1.0 | 494 | 1.0 |
|
Lubricating oils | ||||||||
| Ever Use | 1222 | (3) | 40 | 0.9 (0.6, 1.2) | 32 | 1.0 (0.7, 1.5) | 7 | 0.5 (0.2, 1.2) |
| Never Use | 46394 | (97) | 1,925 | 1.0 | 1,388 | 1.0 | 524 | 1.0 |
|
Metals | ||||||||
| Ever Use | 1797 | (4) | 64 | 1.0 (0.7, 1.2) | 46 | 1.0 (0.7, 1.3) | 18 | 1.0 (0.6, 1.6) |
| Never Use | 45830 | (96) | 1,901 | 1.0 | 1,375 | 1.0 | 512 | 1.0 |
|
Paints | ||||||||
| Ever Use | 2962 | (6) | 115 | 1.0 (0.8, 1.2) | 88 | 1.1 (0.8, 1.3) | 27 | 0.7 (0.5, 1.1) |
| Never Use | 44668 | (94) | 1,850 | 1.0 | 1,332 | 1.0 | 504 | 1.0 |
|
Pesticides | ||||||||
| Ever Use | 725 | (2) | 30 | 1.1 (0.7, 1.5) | 26 | 1.3 (0.9, 2.0) | 4 | 0.4 (0.1, 1.3) |
| Never Use | 46899 | (98) | 1,935 | 1.0 | 1,395 | 1.0 | 526 | 1.0 |
|
Soldering materials | ||||||||
| Ever Use | 1203 | (3) | 48 | 1.1 (0.8, 1.4) | 36 | 1.1 (0.8, 1.6) | 11 | 0.9 (0.5, 1.7) |
| Never Use | 46430 | (97) | 1,918 | 1.0 | 1,385 | 1.0 | 520 | 1.0 |
|
Solvents | ||||||||
| Ever Use | 2367 | (5) | 105 | 1.1 (0.9, 1.3) | 74 | 1.1 (0.8, 1.3) | 31 | 1.2 (0.8, 1.7) |
| Never Use | 44948 | (95) | 1,849 | 1.0 | 1,339 | 1.0 | 496 | 1.0 |
|
Stains | ||||||||
| Ever Use | 953 | (2) | 28 | 0.8 (0.5, 1.1) | 22 | 0.8 (0.5, 1.3) | 6 | 0.6 (0.3, 1.5) |
| Never Use | 46678 | (98) | 1,938 | 1.0 | 1,399 | 1.0 | 525 | 1.0 |
|
Total number of agents | ||||||||
| 2+ agents | 5074 | (11) | 195 | 1.0 (0.8, 1.1) | 150 | 1.1 (0.9, 1.3) | 44 | 0.8 (0.6, 1.1) |
| 1 agent | 6903 | (14) | 289 | 1.0 (0.9, 1.2) | 215 | 1.1 (0.9, 1.3) | 73 | 0.9 (0.7, 1.2) |
| Never Use | 35663 | (75) | 1,482 | 1.0 | 1,056 | 1.0 | 414 | 1.0 |
| p value for trend4 0.30 | p value for trend4 0.47 | p value for trend4 0.39 | ||||||
1
Lifetime exposure to agent defined as affirmative response to the question “Have you handled [agent] at least once a week in any job?"
2
Hazard ratios are adjusted for race/ethnicity, education, income, parity and age at first birth
3
Competing subtypes were censored at time of diagnosis; 14 subtypes unknown
4
Test for trend among exposed only
Note: Differences in the total numbers are due to missing values