Table 2. Sensitivity and specificity, ROC area, PPV, NPV, number of patients of NE, BAEPs, SEPs, MRS, NPS for diagnostic test of MRI and grading of MRI ND-LCH.95% Confidence Intervals in parentheses.
| Sensitivity | Specificity | ROC area | PPV | NPV | N° patients | |
|---|---|---|---|---|---|---|
| MRI | ||||||
| NE | 52.9%(27.8%-77.0%) | 90.0%(55.5%-99.7%) | 0.71(0.50–0.86) | 90.0%(55.5%-99.7%) | 52.9%(27.8%-77.0%) | 27 |
| BAEPs | 29.4%(10.3%-56.0%) | 90.0%(55.5%-99.7%) | 0.60(0.39–0.78) | 83.3%(35.9%-99.6%) | 42.9%(21.8%-66.0%) | 27 |
| SEPs | 70.6%(44.0%-89.7%) | 100.0%(69.2%-100%)* | 0.85(0.66–0.96) | 100.0%(73.5%-100%)* | 66.7%(38.4%-88.2%) | 27 |
| MRS | 52.9%(27.8%-77.0%) | 90.0%(55.5%-99.7%) | 0.71(0.50–0.86) | 90.0%(55.5%-99.7%) | 52.9%(27.8%-77.0%) | 27 |
| NPS# | 22.2%(2.8%-60.0%) | 71.4%(29.0%-96.3%) | 0.47(0.20–0.70) | 50.0%(6.8%-93.2%) | 41.7%(15.2%-72.3%) | 16 |
| Grading of MRI cut-off grading level > 1 | ||||||
| NE | 80.0%(44.4%-97.5%) | 88.2%(63.6%-98.5%) | 0.84(0.66–0.96) | 80.0%(44.4%-97.5%) | 88.2%(63.6%-98.5%) | 27 |
| BAEPs | 30.0%(6.7%-65.2%) | 82.5%(56.6%-96.2%) | 0.56(0.35–0.75) | 50.0%(11.8%-88.2%) | 66.7%(43.0%-85.4%) | 27 |
| SEPs | 90.0%(55.5%-99.7%) | 82.4%(56.6%-96.2%) | 0.86(0.66–0.96) | 75.0%(42.8%-94.5%) | 93.3%(68.1%-99.8%) | 27 |
| MRS | 50.0%(18.7%-81.3%) | 70.6%(44.0%-89.7%) | 0.60(0.39–0.78) | 50.0%(18.7%-81.3%) | 70.6%(44.0%-89.7%) | 27 |
| NPS# | 14.3%(0.4%-57.9%) | 66.7%(29.9%-92.5%) | 0.40(0.15–0.65) | 25.0%(0.6%-80.6%) | 50.0%(21.1%-78.9%) | 16 |
This is Table 2 footnote.
BAEPs: brainstem auditory evoked potentials; MRI: Magnetic Resonance imaging; MRS: Magnetic Resonance Spectroscopy; NE: neurological examination; NPS: neuropsychological evaluation; NPV: negative predictive value;PPV, positive predictive value; ROC: Receiver operating characteristic;SEPs: somatosensory evoked potentials; VEPs: visual evoked potentials.
#: Neuropsychological evaluation was performed in 16 out of 27 patients either for patient’s refusal or because no neuropsychologist was available the date of planned evaluation.
(*) one-sided, 97.5% confidence interval