Table 1.
Effect of reversal of high fat diet, enalapril, or menhaden oil in diet-induced obese or type 2 diabetic rats on change in body weight, nonfasting blood glucose, hemoglobin A1C, steatosis, and epididymal fat pad.
| Condition | Start weight (g) |
End weight (g) |
Blood glucose (mg/dL) |
Hb A1C (%) |
Steatosis (% area) |
Epididymal fat pad (g) |
|---|---|---|---|---|---|---|
| Control (12) | 326 ± 3 | 491 ± 9 | 149 ± 10 | 6.6 ± 0.4 | 3.0 ± 0.5 | 2.8 ± 0.1 |
| Obese (11) | 329 ± 3 | 560 ± 18a | 144 ± 6 | 7.0 ± 0.7 | 5.4 ± 0.7a | 5.9 ± 0.6a |
| Obese + Normal diet (10) | 320 ± 3 | 496 ± 11d | 133 ± 5 | 7.8 ± 0.8 | 2.7 ± 0.3d | 3.1 ± 0.2d |
| Obese + enalapril (12) | 311 ± 1 | 489 ± 12d | 149 ± 4 | 6.3 ± 0.4 | 4.1 ± 0.6 | 3.3 ± 0.3d |
| Obese + menhaden oil (12) | 312 ± 2 | 585 ± 12a | 152 ± 9 | 5.8 ± 0.5 | 4.0 ± 0.5 | 5.8 ± 0.4a |
|
| ||||||
| Diabetic (10) | 325 ± 4 | 493 ± 24 | 382 ± 20a,d | 14.6 ± 1.0a,d | 7.7 ± 1.2a | 2.8 ± 0.3d |
| Diabetic + normal diet (10) | 321 ± 3 | 413 ± 21b | 418 ± 25a,b,d | 11.9 ± 2.0a,b,d | 3.1 ± 0.5c | 1.6 ± 0.3b |
| Diabetic + enalapril (11) | 315 ± 3 | 416 ± 9b,c | 415 ± 23a,b,d | 11.9 ± 1.6a,b,d | 3.4 ± 0.8c | 2.5 ± 0.1d |
| Diabetic + menhaden oil (11) | 310 ± 4 | 450 ± 23b | 364 ± 21a,b,d | 9.5 ± 1.0a,b,c,d | 5.2 ± 0.8 | 3.3 ± 0.5b,d |
Data are presented as the mean ± S.E.M. a P < 0.05 compared to control; b P < 0.05 compared to obese matched condition; c P < 0.05 compared to diabetic; d P < 0.05 compared to obese. Parentheses indicate the number of experimental animals.