Table 3.
Effect of reversal of high fat diet, enalapril, or menhaden oil in diet-induced obese or type 2 diabetic rats on motor and sensory nerve conduction velocity, thermal nociception, and intraepidermal nerve fiber density.
| Condition | MNCV (m/sec) |
SNCV (m/sec) |
Thermal nociception (sec) |
Intraepidermal nerve fiber (profiles/mm) |
|---|---|---|---|---|
| Control (12) | 61.3 ± 1.3 | 21.0 ± 0.4 | 10.0 ± 0.6 | 15.1 ± 0.5 |
| Obese (11) | 60.4 ± 2.3 | 18.5 ± 0.4a | 15.5 ± 0.7a | 10.3 ± 0.7a |
| Obese + normal diet (10) | 58.1 ± 2.2 | 19.1 ± 0.5a | 13.4 ± 1.0 | 11.6 ± 1.0a |
| Obese + enalapril (12) | 60.2 ± 2.6 | 19.7 ± 0.3 | 11.9 ± 0.6d | 14.1 ± 0.7d |
| Obese + menhaden oil (12) | 64.3 ± 2.9 | 20.4 ± 0.3d | 11.3 ± 0.7d | 14.1 ± 0.4d |
|
| ||||
| Diabetic (10) | 44.3 ± 1.6a,d | 17.3 ± 0.3a | 17.4 ± 1.0a | 10.7 ± 0.9a |
| Diabetic + normal diet (10) | 47.3 ± 1.4a,b,d | 18.6 ± 0.4a | 15.9 ± 0.9a | 12.8 ± 0.8 |
| Diabetic + enalapril (11) | 48.5 ± 1.8a,b | 19.0 ± 0.5 | 11.9 ± 0.8c | 14.1 ± 0.9c |
| Diabetic + menhaden oil (11) | 52.3 ± 1.6b,c | 20.0 ± 0.4c | 10.6 ± 0.6c | 14.6 ± 0.9c |
Data are presented as the mean ± S.E.M. a P < 0.05 compared to control; b P < 0.05 compared to obese matched condition; c P < 0.05 compared to diabetic; d P < 0.05 compared to obese. Parentheses indicate the number of experimental animals.