Table 1. Overview of definitions used for complications and anastomotic leakage in the selected studies.
Abreviations; postoperative day (POD), anastomotic leak (AL), systemic inflammatory response syndrome (SIRS), computed tomography scan (CT), urinary tract infection (UTI).
| CRP as marker for postoperative complications | |||||
| Study | year | Organ | Cut-off | POD | Definition |
| Adamina [26] | 2014 | Colorectal | 56 mg/L | 4 | Infectious complications, graded according to Clavien-Dindo. Cut-off applies in absence of clinical signs. |
| Kørner [27] | 2009 | Colorectal | 190 mg/L | 3 | Intraabdominal infection; AL, abscess or diffuse peritonitis |
| Lane [28] | 2012 | Colorectal | 150 mg/L | 2 | Adverse events: including infective complications, postoperative organ dysfunction and prolonged length of stay |
| MacKay [15] | 2009 | Colorectal | 145 mg/L | 4 | All infective complications |
| Mokart [29] | 2005 | All abdominal | 93 mg/L | 1 | Postoperative sepsis (SIRS + infection) |
| Nason [30] | 2014 | Colorectal | 148 mg/L | 4 | Infective complications; AL confirmed by CT, wound infection with purulent drainage |
| Platt [14] | 2012 | Colorectal | 170 mg/L | 3 | Postoperative infective complications (surgical site and remote site infection) |
| Straatman [1] | 2014 | Major abdominal surgery | 145 mg/L | 3 | Postoperative complications defined by Clavien-Dindo, with a cut-off for major complications (grades 3 and up) |
| Warschkow [31] | 2012 | Pancreas | 94 mg/L | 7 | Postoperative inflammatory complications; pancreatic fistula, anastomotic leak, cholangitis, pancreatitis, wound infections, abscesses, pneumonia, UTI |
| Warschkow [13] | 2012 | Gastro-esophageal | 141 mg/L | 4 | Postoperative infections; AL, abscess, pneumonia, wound infection, UTI, colitis |
| Warschkow [17] | 2012 | Colorectal | 135 mg/L | 4 | Postoperative infectious complications: Any septic event, both intra- and extra- abdominal infections |
| Warschkow [10] | 2011 | Colorectal | 123 mg/L | 4 | Inflammatory complications; AL (confirmed by imaging or operation), UTI, wound infection, pneumonia, central line infections. |
| Welsch [12] | 2008 | Pancreas | 140 mg/L | 4 | Fistula, leak, abscess, wound infection, pneumonia, cholangitis, central line infection, UTI, necrotizing pancreatitis, infectious bilioma or pleural effusion |
| CRP as marker for anastomotic leakage (AL) | |||||
| Study | year | Organ | Cut-off | POD | Definition |
| Almeida [32] | 2012 | Colorectal | 140 mg/L | 3 | AL defined as free feacal fluid in the abdomen diagnosed by drain production or CT-scan imaging |
| Deitmar [33] | 2009 | Oesophagus | 135 mg/L | 2 | Leak of anastomosis or gastric staple line confirmed with endoscopy |
| Dutta [34] | 2011 | Esophago-gastric | 180 mg/L | 3 | AL confirmed with CT, contrast study or upor reoperation |
| Garcia-Granero [35] | 2013 | Colorectal | 147 mg/L | 3 | AL confirmed with imaging or upon reoperation |
| Oberhofer [36] | 2012 | Colorectal | 99 mg/L | 3 | AL (imaging), abscess, wound infection, pneumonia, central line infection, UTI |
| Ortega- Deballon [16] | 2010 | Colorectal | 125 mg/L | 4 | AL: feacal drain production, collection at anastomosis site with imaging, dehiscence during reoperation |
| Pedersen [37] | 2012 | Colorectal (MIS) | 200 mg/L | 3 | AL diagnosed in patients with acute abdomen, upon imaging or upon reoperation |
| Scepanovic [38] | 2013 | Stomach, small bowel, colon | 135 mg/L | 3 | AL defined as clinical presence of enteric contents within the drains |
| Welsch [9] | 2007 | Rectal | 140 mg/L | 3&4 | AL (imaging), abscess, wound infection, pneumonia, central line infection, UTI |