Figure 1.

Regions of interest. Axial T1-weighted images, T2-weighted images, apparent diffusion coefficient (ADC) maps, and fractional anisotropy (FA) maps at two different levels of cerebrum showing the manually drawn regions of interest: (a) lower level and (b) higher level. ADC and FA values were measured in eight different regions of interest in the cerebrum: that is, in the thalamus, the posterior limb of the internal capsule and the lentiform nucleus, the white matter (within the frontal and posterior white matter), and the cortical grey matter (within the frontal, parietal, and occipital cortices). Regions of interest were always drawn by the same observer by looking at the same time at the ADC and FA maps and the corresponding T1- and T2-weighted imaging.