Table 1.

Development of EAE in wt and aif-1^−/− mice.

Genotype	Day of onseta	Days to peak clinical diseaseb	Mean clinical score	Cumulative disease index (%)c	Incidence (%)d	Maximum score	Mortality
wt	8.1 ± 0.61	10.1 ± 0.84	1.46 ± 0.13	28 ± 4.5	15/16 (94%)	2.6 ± 0.26	None
aif-1−/−	8.6 ± 1.3	10.6 ± 0.84	0.67 ± 0.05***	13 ± 4.5*	8/13 (62%)	1.5 ± 0.33*	None

Data are represented as mean ± SEM.

^*P < 0.05,

^***P < 0.0001.

^aSecond consecutive day in which an animal scored ≥0.5.

^bTime for each mouse to reach its highest score.

^cSum of the daily EAE scores for each mouse for entire duration of the experiment.

^dFraction of animals with scores ≥0.5 at a given time during the entire disease course.