Table 3. Distribution of the global M. tuberculosis lineages by baseline patient characteristics and M. tuberculosis –genotypes by concordance of isolates from sputum and blood samples.
| Variable | ConcordantN=25; N (%) | DiscordantN=26; N (%) | Odds ratio (95% CI) | p-value |
|---|---|---|---|---|
| Euro-American lineage in sputum and/or blood | ||||
| No | 6 (24.0) | 1 (3.8) | Reference | 0.050 |
| Yes | 19 (76.0) | 25 (96.2) | 7.89 (0.99-71.21) | |
| East-African-Indian lineage in sputum and/or blood | ||||
| No | 19 (76.0) | 22 (84.6) | Reference | 0.499 |
| Yes | 6(24.0) | 4 (15.4) | 0.58 (0.15-2.22) | |
| CD4 count/ mm 3 | ||||
| >50 | 10 (40.0) | 8 (30.8) | Reference | 0.565 |
| <50 | 15 (60.0) | 18 (69.2) | 1.50 (0.48-4.66) | |
| Age group | ||||
| <30 | 8 (32.0) | 11 (42.3) | Reference | 0.452 |
| 30-39 | 13 (52.0) | 9 (34.6) | 0.50 (0.15-1.72) | |
| =/>40 | 4 (16.0) | 6 (23.1) | 1.09 (0.24-4.88) | |
| Sex | ||||
| Female | 15 (60.0) | 10 (38.5) | Reference | 0.165 |
| Male | 10 (40.0) | 16 (61.5) | 2.40 (0.79-7.28) | |
| Karnofsky performance score | ||||
| 70 and above | 9 (36.0) | 9 (34.6) | Reference | 0.918 |
| 50-60 | 16 (64.0) | 17 (65.4) | 0.94 (0.29-3.00) | |
| On ART at enrollment (n=50) | ||||
| Yes | 5 (20.8) | 5 (19.2) | Reference | 0.889 |
| No | 19 (79.2) | 21 (80.8) | 1.11 (0.29-4.18) | |
| Previously treated for TB | ||||
| No | 22 (88.0) | 25 (96.2) | Reference | 0.350 |
| Yes | 3 (12.0) | 1 (3.8) | 0.29 (0.03-3.19) | |
| Sputum smear status (n=49) | ||||
| Negative | 17 (70.8) | 14 (56.0) | Reference | 0.377 |
| Positive | 7 (29.2) | 11 (44.0) | 1.91 (0.60-6.08) | |
| MGIT (sputum) time to detection (days) | ||||
| ≥12 | 9 (36.0) | 6 (23.1) | Reference | 0.373 |
| 7-11 | 7 (28.0) | 12 (46.2) | 2.57 (0.60-10.98) | |
| ≤6 | 9 (36.0) | 8 (30.8) | 1.33 (0.32-5.58) | |
| Blood culture time to detection (days) | ||||
| ≥30 | 8 (32.0) | 6 (23.1) | Reference | 0.742 |
| 22-29 | 11 (44.0) | 12 (46.2) | 1.45 (0.37-5.68) | |
| ≤21 | 6 (24.0) | 8 (30.8) | 1.78 (0.38-8.29) | |
| LJ (sputum) culture colony counts | ||||
| No Growth | 5 (20.0) | 4 (15.4) | 0.565 (0.133-2.399) | 0.703 |
| <10 | 6 (24.0) | 4 (15.4) | 0.407 (0.115-1.934) | |
| 10-100 | 12 (48.0) | 17 (65.4) | Reference | 0.453 |
| >100 | 2 (8.0) | 1 (3.8) | 0.353 (0-3.092) |
Abbreviations, LJ- Lowenstein Jensen, MGIT- Mycobacterial Growth Indicator Tube, OR = Odds Ratio.
OR for discordant MTB-lineages, P values for categorical variables were based on the 2-sided Fisher’s exact test.