Table 1. Baseline Demographics and Comorbidity in Development and Validation cohorts.
Univariate analysis performed with Chi-Squared or Fisher’s exact test for dichotomous data, Mann-Whitney U-test for non-normally distributed continuous data and student’s t-test for normally distributed continuous data.
| Patient Demographics or Comorbidity | Centre 1 N = 475 | Centre 2 N = 286 | Total N = 761 | p-value |
|---|---|---|---|---|
| Age (median) | 76.00 | 75.00 | 75.00 | 0.239 |
| Age (IQR) | (70.0–80.0) | (70.0–79.0) | (70.0–80.0) | |
| Male Gender | 416/471 | 260/286 | 676/757 | 0.278 |
| Male Gender (%) | (88.3%) | (90.9%) | (89.3%) | |
| Estimated Glomerular Filtration Rate (ml/min/1.73m2) (median) | 70.00 | 66.30 | 68.65 | 0.044 |
| Estimate GFR (ml/min/1.73m2) (IQR) | (53.4–84.2) | (51.8–79.6) | (52.6–82.4) | |
| Ischaemic Heart Disease * | 240/475 | 114/248 | 354/723 | 0.273 |
| Ischaemic Heart Disease (%) | (50.5%) | (46.0%) | (49.0%) | |
| Chronic Obstructive Pulmonary Disease † | 174/475 | 14/286 | 188/761 | < 0.001 |
| Chronic Obstructive Pulmonary Disease (%) | (36.6%) | (4.9%) | (24.7%) | |
| Hypertension ‡ | 332/475 | 185/259 | 517/734 | 0.673 |
| Hypertension (%) | (69.9%) | (71.4%) | (70.4%) | |
| Hypercholesterolaemia § | 337/475 | 140/177 | 477/652 | 0.037 |
| Hypercholesterolaemia (%) | (70.9%) | (79.1%) | (73.2%) | |
| Current Smoking | 180/475 | 47/252 | 227/727 | < 0.001 |
| Current Smoking (%) | (37.9%) | (18.7%) | (31.2%) | |
| Diabetes || | 70/472 | 39/253 | 109/725 | 0.828 |
| Diabetes (%) | (14.8%) | (15.4%) | (15.0%) | |
| Top Endograft Diameter (median) | 28.00 | 28.00 | 28.00 | 0.920 |
| Top Endograft Diameter (IQR) | (26.0–30.0) | (26.0–32.0) | (26.0–31.0) | |
| AortoUniIliac Device | 61/637 | 3/63 | 64/700 | 0.257 |
| AortoUnIliac Device (%) | (9.6%) | (4.8%) | (9.1%) |
*History of angina; and history or ECG evidence of previous myocardial infarction
†Receiving treatment for COPD, previously diagnosed with COPD, FEV1<80% predicted or FEV1/FVC<0.7
‡Receiving treatment or dietary advice for hypertension or recorded blood pressure of 140/90mmHg or greater on at least two occasions
§Receiving treatment or dietary advice for hypercholesterolaemia
||Receiving treatment or dietary advice for type I or type II diabetes mellitus