Table 2.

Association of gray and white matter atrophy with parameters of glucose metabolism

	Atrophy
	Gray matter			White matter
	Beta	P value	R 2	Beta	P value	R 2
Fasted glucose	0.007	0.924	0.336	−0.189	0.028*	0.191
AUC glucose	−0.042	0.586	0.337	−0.148	0.084	0.179
Fasted insulin	0.002	0.983	0.336	−0.082	0.325	0.166
AUC insulin	−0.059	0.420	0.339	−0.076	0.361	0.165
HOMA-IS index	−0.003	0.968	0.336	0.105	0.213	0.170
Insulinogenic Index	−0.076	0.302	0.342	0.087	0.292	0.167

Atrophy is defined as the difference between intracranial and brain volumes divided by intracranial volume multiplied by hundred percent. All insulin values were log-transformed. Associations are expressed as standardized Beta with corresponding P-values. Results are from linear regression analysis corrected for age, gender and offspring- partner status

AUC Area under the curve, HOMA-IS Homeostatic model assessment of insulin sensitivity

*p < 0.05