Table 3.

Association of magnetization transfer imaging (MTI)-derived integrity of gray and white matter micro-structure with parameters of glucose metabolism

	Gray matter						White matter
	Mean MTR			Peak height			Mean MTR			Peak height
	Beta	P value	R 2	Beta	P value	R 2	Beta	P value	R 2	Beta	P value	R 2
Fasted glucose	−0.124	0.166	0.159	−0.150	0.084	0.216	0.058	0.528	0.106	−0.050	0.572	0.181
AUC glucose	−0.165	0.063	0.170	−0.113	0.191	0.207	−0.031	0.737	0.103	−0.133	0.127	0.194
Fasted insulin	−0.068	0.432	0.150	−0.213	0.010*	0.239	0.110	0.213	0.114	−0.189	0.024*	0.213
AUC insulin	−0.181	0.033*	0.177	−0.276	0.001*	0.269	−0.033	0.709	0.104	−0.264	0.001*	0.246
HOMA-IS index	0.081	0.351	0.152	0.220	0.008*	0.241	−0.110	0.217	0.114	0.184	0.030*	0.210
Insulinogenic index	−0.151	0.075	0.168	−0.289	<0.001*	0.277	0.018	0.833	0.103	−0.210	0.011*	0.221

All insulin values were log transformed. The standardized beta and corresponding P values are shown for analysis using individual brain volume corrected for head size. Results are from linear regression analysis corrected for age, gender and offspring partner status

MTR magnetization transfer ratio, AUC area under the curve, HOMA-IS homeostatic model assessment of insulin sensitivity

*p < 0.05