Table 2.
Biochemical data of mice injected with Ad-NK4 or PBS
| Test | Day 1 | Day 7 | Day 14 | |||
|---|---|---|---|---|---|---|
| Ad-NK4 | PBS | Ad-NK4 | PBS | Ad-NK4 | PBS | |
| TP (g/dl) | 5.4 ± 0.2 | 4.7 ± 0.1 | 4.6 ± 0.1 | 4.9 ± 0.1 | 5.0 ± 0.2 | 4.8 ± 0.1 |
| ALB (g/dl) | 2.8 ± 0.0 | 2.8 ± 0.1 | 2.6 ± 0.0 | 3.0 ± 0.0 | 2.8 ± 0.1 | 2.8 ± 0.0 |
| BUN (mg/dl) | 25.8 ± 1.0 | 23.6 ± 1.4 | 22.8 ± 0.9 | 24.5 ± 1.0 | 25.2 ± 0.9 | 28.0 ± 1.6 |
| CRE (mg/dl) | 0.14 ± 0.01 | 0.16 ± 0.01 | 0.13 ± 0.01 | 0.15 ± 0.02 | 0.14 ± 0.02 | 0.15 ± 0.01 |
| Na (mEq/l) | 153 ± 1 | 149 ± 1 | 151 ± 1 | 151 ± 1 | 149 ± 1 | 151 ± 1 |
| K (mEq/l) | 4.8 ± 0.2 | 4.4 ± 0.2 | 4.1 ± 0.2 | 3.9 ± 0.4 | 5.5 ± 0.5 | 4.3 ± 0.1 |
| Cl (mEq/l) | 101 ± 2 | 104 ± 0 | 106 ± 1 | 104 ± 1 | 105 ± 1 | 103 ± 2 |
| Ca (mg/dl) | 9.2 ± 0.1 | 9.6 ± 0.1 | 9.5 ± 0.1 | 9.5 ± 0.0 | 9.3 ± 0.1 | 9.5 ± 0.2 |
| IP (mg/dl) | 7.9 ± 0.4 | 9.7 ± 0.9 | 8.1 ± 0.1 | 7.8 ± 0.3 | 10.0 ± 0.9 | 7.1 ± 0.4 |
| AST (IU/l) | 191 ± 18 | 80 ± 18 | 383 ± 273 | 93 ± 32 | 347 ± 96 | 95 ± 13 |
| ALT (IU/l) | 131 ± 30 | 26 ± 7 | 312 ± 238 | 28 ± 3 | 244 ± 96 | 29 ± 3 |
| ALP (IU/l) | 198 ± 10 | 378 ± 43 | 407 ± 60 | 408 ± 79 | 448 ± 62 | 324 ± 30 |
| LDH (IU/l) | 3,352 ± 359 | 2,686 ± 826 | 2,535 ± 847 | 2,142 ± 287 | 2,622 ± 592 | 2,087 ± 271 |
| CPK (IU/l) | 1,262 ± 408 | 1,032 ± 412 | 432 ± 70 | 3,734 ± 3,283 | 4,493 ± 3,156 | 1,297 ± 387 |
| T-CHO (mg/dl) | 219 ± 11 | 147 ± 5 | 161 ± 8 | 169 ± 8 | 153 ± 8 | 176 ± 7 |
| TG (mg/dl) | 131 ± 17 | 109 ± 3 | 74 ± 13 | 40 ± 7 | 57 ± 6 | 119 ± 27 |
| T-BIL (mg/dl) | 0.05 ± 0.01 | 0.04 ± 0.00 | 0.09 ± 0.01 | 0.10 ± 0.01 | 0.08 ± 0.01 | 0.07 ± 0.01 |
| GLU (mg/dl) | 106 ± 7 | 169 ± 3 | 187 ± 12 | 173 ± 3 | 197 ± 8 | 192 ± 15 |
Data show average and SE values (n = 6). CrlJ:CD1 mice injected with Ad-NK4 were 5-week old male. Data of untreated CrlJ:CD1 male mice at 11-week old (Japan Charles river, Japan) as follows.
TP, 4.2 ± 0.3 g/dl; ALB, 2.3 ± 0.3 g/dl; BUN, 33.8 ± 8.6 mg/dl; CRE, 0.3 ± 0.09 mg/dl; Na, 153 ± 2 mEq/l; K, 4.6 ± 0.4 mEq/l; Cl, 106.7 ± 4.3 mEq/l; Ca, 8.8 ± 0.3 mg/dl; IP, 7.9 ± 1.5 mg/dl; AST, 76 ± 11 IU/l; ALT, 32 ± 7 IU/l; ALP, 82 ± 31 IU/l; LDH, not available; CPK, 249 ± 96 IU/l; T-CHO, 151 ± 44 mg/dl; TG, 78 ± 58 mg/dl; T-BIL, 0.08 ± 0.03 mg/dl; GLU, 101 ± 35 mg/dl.