Table 2. Expression of Selected Immune-Related Transcripts in Control and Amphetamine Treated Rats.
| Saline Controls | Amphetamine Treated | |||||
|---|---|---|---|---|---|---|
| NCBI Gene Symbol | Mean ± S.E.M. | Expression Rank | Mean ± S.E.M. | Expression Rank | DE P-value | |
| Primarily | Ccr1 | 6059.4 ± 282.2 | 484 | 7714.5 ± 131.9 | 424 | N.S. |
| Expressed | Itgax (Cd11c) | 1874.2 ± 24.6 | 1440 | 1976.7 ± 42.4 | 1358 | 0.0254 |
| in Monocytes | Cd14 | 340.4 ± 12.4 | 5472 | 1624.1± 46.8 | 1580 | 0.0000 |
| Cd163 | 18.6 ± 1.4 | 11504 | 9.8 ± 0.6 | 12282 | N.S. | |
| Cd68 | 578.4 ± 10.0 | 3888 | 957.6± 18.3 | 2471 | 0.0000 | |
| Nos2* | 3171.8 ± 228.5 | 870 | 6261.4± 211.1 | 510 | 0.0069 | |
| Arg1* | 14.1 ± 1.7 | 11901 | 62.2 ± 4.9 | 9161 | 0.0000 | |
| Primarily | Cd2 | 1174.2 ± 12.6 | 2211 | 552.4± 14.5 | 3636 | 0.0000 |
| Expressed | Cd3e | 1994.2 ± 27.7 | 1359 | 714.7± 14.6 | 3033 | 0.0000 |
| in T-Cells | Cd8a | 2551.0 ± 33.1 | 1086 | 998.0± 12.8 | 2390 | 0.0000 |
| Cd28 | 306.9 ± 5.1 | 5790 | 87.8 ± 2.1 | 8409 | 0.0000 | |
| Cd247 | 1848.6 ± 18.7 | 1459 | 635.4 ± 11.7 | 3307 | 0.0000 | |
| Primarily | Cd19 | 2206.6 ± 41.6 | 1250 | 1126.1 ± 20.5 | 2181 | 0.0003 |
| Expressed | Cd22 | 1362.0 ± 21.3 | 1943 | 991.8 ± 19.5 | 2409 | N.S. |
| in B-Cells | Cd79b | 4218.4 ± 92.8 | 658 | 2214.1 ± 46.3 | 1221 | 0.0100 |
| Cd180** | 617.3 ± 12.3 | 3676 | 346.3 ± 9.2 | 4870 | 0.0008 | |
| Ly86 | 536.7 ± 8.5 | 4116 | 379.7 ± 6.7 | 4620 | 0.0140 | |
| Primarily | Camp(LL-37) | 1535.7 ± 91.2 | 1747 | 1370.5 ± 50.0 | 1806 | N.S. |
| Expressed | Elane | 87.2 ± 3.5 | 8977 | 207.6 ± 7.7 | 6259 | 0.0000 |
| in Neutrophils | Mpo | 17.1 ± 1.6 | 11633 | 11.7 ± 0.8 | 12003 | N.S. |
| Mme | 2.3 ± 0.3 | 14332 | 1.3 ± 0.1 | 15028 | N.D. | |
| Prtn3 | 0.4 ± 0.0 | 16292 | 1.3 ± 0.1 | 14972 | N.D. | |
| Ctsg | 3.9 ± 0.7 | 13676 | 1.6 ± 0.1 | 14704 | N.D. | |
| Expressed | Cd300a | 968.5 ± 20.4 | 2589 | 1575.0 ± 19.3 | 1626 | 0.0000 |
| In most | Cd44 | 8363.9 ± 146.3 | 380 | 8670.4 ± 84.9 | 380 | N.S. |
| Leukocytes | Cd48 | 4284.9 ± 48.7 | 644 | 2925.8 ± 43.1 | 957 | 0.0033 |
| Cd84 | 252.6 ± 6.5 | 6362 | 320.7 ± 6.6 | 5091 | 0.0051 | |
| Cd97 | 16286.2 ± 405.0 | 217 | 14734.5 ± 209.7 | 253 | N.S. | |
| Sell | 18067.8 ± 429.1 | 194 | 16497.2 ± 243.4 | 222 | N.S. | |
*These genes may also be in dendritic cells as well as monocytes but the levels of dendritic cells are much lower in circulating blood than monocytes.
**This gene is also present in plasma cells but the levels of these types of cells in blood would be much lower than B cells in circulating blood.