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. 2015 Jul 15;10(7):e0132866. doi: 10.1371/journal.pone.0132866

Table 1. Software of DMR detection.

Software Method Samples Replicates
DSS Dispersion shrinkage estimate Gamma-Poisson or Beta-Binomial distributions two groups yes
bsseq Smoothing t-test two groups yes
methylSig Beta-binomial two groups yes
eDMR Expectation maximization (EM) algorithm to fit to a bimodal normal distribution two groups yes
MOABS Beta-Binomial hierarchical model two groups yes
BiSeq Design for targeted BS data (RRBS) two or groups no
CpG_MPs Combined hotspot and entropy theory two or more no
ComMet Use HMM model to identify DMR (a tool of bisulfighter). two no