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. Author manuscript; available in PMC: 2016 Jun 17.
Published in final edited form as: Neuron. 2015 Jun 17;86(6):1358–1368. doi: 10.1016/j.neuron.2015.05.020

Figure 2. Development of cued fear extinction parallels clinical response to cognitive behavioral therapy in anxiety disorders.

Figure 2

(A) Reduced fear extinction learning in both mice and human during adolescence (Pattwell et al., 2012b). (B) Diminished treatment response during adolescence based on data from the Child/Adolescent Anxiety Multimodal Study (CAMS) (Walkup et al., 2008) subdivided by developmental stage (A) adolescents show nonsignificant decrease in responsiveness to cognitive behavioral therapy (Drysdale et al., 2014). *Adolescent extinction is significantly lower than childhood and adulthood.