Table 2.

Main Effect of Inflammation on Resting FDG Metabolism 4 Hrs−Baseline (Vaccine) Masked by 4 Hrs–Baseline (Placebo)

Side	Region	Coordinates	Z Score	k	Uncorrected p	Corrected p Peak
L	Posterior insula	−45 −24 10	4.88	384	<.001	.015a
L	Anterior insula	−36 21 3	4.26	283	<.001	.157
R	Posterior insula	40 −22 13	4.09	181	<.001	.274
R	Midfrontal gyrus	30 −7 52	4.05	157	<.001	.304
L	Midfrontal gyrus	−42 15 39	3.58	296	<.001	.800
R	Midfrontal gyrus	46 9 31	3.37	81	<.001	.945

FDG, fluorodeoxyglucose; L, left; R, right.

^aPre-planned region of interest