Fig. 4.

Overlap of MR's (RUNX1, PU.1, and IRF8) predicted target genes in the microglia module (A) compared with genes from the whole data set (Medical Research Council/United Kingdom [MRC/UK]) (B). (A) Predicted regulons (in other words target genes) of RUNX1, PU.1, and IRF8 in the MRC/UK gene expression data. (A) displays only genes that are part of the microglia module. (B) As in (A) but including all predicted target genes of the 3 MRs across all genes in the network. It is of note that n = 14 genes that are regulated by all 3 MRs are present in both (A) and (B). Supplementary Fig. 5 shows the same gene sets as in this figure including all gene names.