Table 1.
Summary of analyses undertaken on genotype distributions of 16 SNPs reported in genetic association studies included in this study
| Study | Articlea,b | Gene(Polymorphism) | Group | N | Genotype (N) | P value(Re-analysis)c | P value(Article) | REH(95% CI)f | HWE Reported | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AB | BB | |||||||||
| A | Dastgerdi andSadeghi (2009) | TP53(R72P) | Case | 144 | 65 | 61 | 18 | 0.534 | - | 0.892 (0.621-1.281) | No |
| Control | - | - | - | - | - | - | NA | - | |||
| B | Bahadoriet al. (2010) | PTPRZ1(rs13241278) | Case | 140 | 46 | 72 | 22 | 0.485 | 0.5 | 1.132(0.803-1.595) | Yes |
| Control | 165 | 65 | 72 | 28 | 0.327 | 0.8 | 0.844(0.613-1.162) | Yes | |||
| PTPRZ1(SNPrs2693657) | Case | 140 | 46 | 71 | 23 | 0.607 | 0.8 | 1.091(0.776-1.536) | Yes | ||
| Control | 165 | 49 | 82 | 34 | 1.000 | 0.99 | 1.004(0.738-1.366) | Yes | |||
| C | Shariatiet al. (2011) | NRG1(SNP8N-RG241930) | Case | 95 | 8 | 36 | 51 | 0.798 | (χ2=0.07,df=2, P≤ 0.1) | 0.891(0.543-1.463) | Yesbut incorrect |
| Control | 95 | 10 | 60 | 25 | 0.005 | (χ2=0.12,df=2, P≤0.1) | 1.897(1.215-2.962) | Yesbut incorrect | |||
| D | Azadeh Sayadet al. (2012) | LPL(Intronic HindIII) | Case | 100 | 58 | 40 | 2 | 0.145 | - | 1.857(0.86-4.01) | No |
| Control | 100 | 44 | 52 | 4 | 0.030 | - | 1.96(1.098-3.499) | No | |||
| E | Pouresmailiet al. (2013) | VDRrs1544410 | Case | 64 | 14 | 33 | 17 | 0.797 | - | 1.07(0.654-1.748) | No |
| Control | 82 | 13 | 33 | 36 | 0.330 | - | 0.763(0.479-1.215) | No | |||
| F | Aida Sayadet al. (2013) | IL-2(-475 IL-2) | Case | 100 | 96 | 4 | 0 | 1.000 | - | NA | No |
| Control | 100 | 100 | 0 | 0 | NAd | - | NA | No | |||
| IL-2(-631 IL-2) | Case | 100 | 98 | 2 | 0 | 1.000 | - | NA | No | ||
| Control | 100 | 100 | 0 | 0 | NA | - | NA | No | |||
| G | Pirahmadiet al. (2013) | TLR4(D299G) | Case | 350 | 303 | 42 | 5 | 0.017 | - | 0.54(0.316-0.922) | No |
| Control | 350 | 315 | 35 | 0 | 1.000 | - | NA | No | |||
| TLR4 | Case | 350 | 296 | 54 | 0 | 0.246 | - | NA | No | ||
| (T399I) | Control | 350 | 294 | 56 | 0 | 0.148 | - | NA | No | ||
| H | Zamaniet al. (2014) | CD14(1359G/T) | Case | 100 | 60 | 33 | 7 | 0.403 | - | 0.805(0.479-1.353) | Yes |
| Control | 100 | 63 | 32 | 5 | 0.766 | - | 0.901(0.509-1.598) | Yes | |||
| CTLA4(49A/G) | Case | 100 | 61 | 35 | 4 | 1.000 | - | 1.091(0.776-1.536) | Yes | ||
| Control | 100 | 58 | 36 | 6 | 1.000 | - | 1.004(0.738-1.366) | Yes | |||
| I | TaghizadehMortezaeeet al. (2014) | ESR1(351A/G) | Case | 276 | 93 | 128 | 55 | 0.385 | - | 0.895(0.704-1.138) | Yes |
| Control | 157 | 55 | 77 | 25 | 0.738 | - | 1.038(0.75-1.437) | Yes | |||
| ESR1(397T/C) | Case | 276 | 78 | 133 | 65 | 0.635 | - | 0.934(0.737-1.183) | Yes | ||
| Control | 157 | 50 | 74 | 33 | 0.630 | - | 0.911(0.664-1.25) | Yes | |||
| CYP1A1(I462V) | Case | 276 | 241 | 35 | 0 | 0.611 | - | NA | Yes | ||
| Control | 157 | 144 | 13 | 0 | 1.000 | - | NA | Yes | |||
| J | Motovali-Bashiet al. (2014) | XPD(K751Q) | Case | 288 | 80 | 144 | 64 | 1.000 | - | 1.006(0.798-1.269) | No |
| Control | 352 | 112 | 112 | 128 | 9.8×10-12e | - | 0.468(0.374 -0.585) | No | |||
a; Articles are sorted chronologically and those reporting a significant association are shown in bold type, b; Full details of these articles are given in Appendix 1 of the Supplementary Online Information at www.celljournal.org, c; Significant P values are shown in bold type, d; Not applicable, e; Since this P value approached zero using the Chi-square-based test, HWE exact test was used to obtain the exact P value and f; REH value is reported as ‘NA’ when any genotype count is zero since ω can only take non-zero values. REH CI not containing zero are shown in bold type.