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. 2015 Apr 16;26(8):2137–2146. doi: 10.1007/s00198-015-3118-x

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — To measure porosity, two referent attenuation values are required P: the background (muscle, water etc.) and B: the fully mineralized bone matrix (1200 mg HA/cm³). The proportion of the voxel volume occupied by mineralized bone matrix is its level of fullness (LOF) and is estimated as (LOF) % = (A_i-P)/(B-P), where A_i is the attenuation of voxel i. From LOF, the void volume of each voxel or level of emptiness (porosity) = 100–LOF (%)