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. 2015 May;208(5):241–252. doi: 10.1016/j.cancergen.2015.03.008

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Results from a transcriptomic analysis of the OCM: Downregulated genes were, dependening on their level colored in green, upregulated in red. The analyzed cell lines are from the left to the right: U2OS osteosarcoma treated with ibandronate and simvastatin; PC-3 prostate cancer cells treated with ibandronate. The labels are the actual gene names according to the NCBI gene database. Abbreviations: MTHFD, methylenetetrahydrofolate dehydrogenase; MTHFR, methylenetetrahydrofolate reductase; DHFR, dihydrofolate reductase; TYMS, thymidylate synthetase; SHMT, serine hydroxymethyltransferase; AHCYL1, adenosylhomocysteinase-like 1; MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase; DNMT1, DNA (cytosine-5-)-methyltransferase 1; MAT2B, methionine adenosyltransferase II, beta.

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