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. 2015 Jul;99:219–229. doi: 10.1016/j.steroids.2015.02.022

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 1 — Synthesis rates of de novo transcription of Atf3 and Ch25h following IFN- $γ$ treatment and RNA abundance of Irf1, Ch25h and Atf3 upon Poly (I:C) treatment. (a) Measurement of de novo transcribed RNA of Atf3 and Ch25h upon IFN- $γ$ treatment in wild-type BMDMs (relative to control treated) in Medium A over an 8-h period. Each point represents transcript synthesis in control treated vs IFN- $γ$ during a 30-min period. Normalised log fold change values were calculated by subtracting the control treated from the IFN- $γ$ treated signal values. Atf3: p = ns; Ch25h: p=1.91E−12. (b) Irf1 abundance in wild-type and Ifnb^−/− BMDMs (relative to control treated t = 0) in Medium A following 10 μg/mL Poly (I:C) treatment. (c) Ch25h abundance in wild-type and Ifnb^−/− BMDMs (relative to control treated t = 0) in Medium A following 10 μg/mL Poly (I:C) treatment. (d) Atf3 abundance in wild-type and Ifnb^−/− BMDMs (relative to control treated t = 0) in Medium A following 10 μg/mL Poly (I:C) treatment.