Figure 1.

Integrated approach for exploiting Streptomyces arsenal to combat the antibiotic resistance. (A) Extensive screening strategies for identifying lead antimicrobials: (a) Compound specific screening (b) Pathogenic organism specific screening. (B) Production and overproduction strategies. The knowledge of synthetic biology, integrated-omics (genomics, proteomics, metabolomics, etc…) and system biology can be used for developing efficient production host. The performance of host can be further ameliorated with media optimization and fermentation technology for optimum production. (C) Compound modification and diversification strategies. By using knowledge of synthetic chemistry, synthetic biology, system biology and integrated-omics, various novel and effective derivatives can be developed using in vivo and in vitro approaches.