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. 2015 Jul 16;5:12144. doi: 10.1038/srep12144

Figure 1. Systemic hyperuricemia induces hypothalamic inflammation in rodents.

Figure 1

(A) Time course of serum UA concentration after the onset of HUAD feeding (n = 6 rats per group; Avg. = average). (B–I) Time course of the induction of mRNA expression of inflammatory mediators, including pro-inflammatory cytokines (Il6, Il1b, Tnfa, Crp, Ccl2) and NF-κB signaling (Nfkbia, Ikbkb, Ikbke) in the hypothalamus of rats fed chow or a HUAD for up to 28 days (n = 6 rats per group). All mRNA species were quantified relative to Gapdh housekeeping gene expression and are presented as fold changes relative to chow-fed controls [fold chow]. All displayed values are the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 versus chow-fed control.