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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Atherosclerosis. 2015 May 16;241(1):176–182. doi: 10.1016/j.atherosclerosis.2015.05.006

Table 3.

Association of Lp-PLA2 levels and risk of incident cardiovascular disease (n=5456)

Model 1* Model 2*
Hazard Ratio†
(95% CI)		 p-value Hazard Ratio
(95% CI)		 p-value
Cardiovascular disease (516 events)
  Lp-PLA2 activity 1.12 (1.01, 1.26) 0.04 1.11 (0.99, 1.25) 0.06
  Lp-PLA2 mass 1.10 (1.01, 1.21) 0.03 1.10 (1.01, 1.21) 0.04
Coronary heart disease (358 events)
  Lp-PLA2 activity 1.18 (1.03, 1.34) 0.01 1.17 (1.02, 1.34) 0.02
  Lp-PLA2 mass 1.15 (1.04, 1.28) 0.01 1.14 (1.03, 1.27) 0.01
Coronary heart disease – Hard (223 events)
  Lp-PLA2 activity 1.22 (1.04, 1.44) 0.02 1.22 (1.02, 1.44) 0.03
  Lp-PLA2 mass 1.29 (1.14, 1.46) <0.001 1.31 (1.15, 1.49) <0.001
*

Model 1: Adjusted for age, gender and race/ethnicity, BMI, diabetes, smoking status, high school education, systolic blood pressure, use of anti-hypertensive medication, total and HDL cholesterol, use of lipid lowering medications, and CRP.

Model 2: Model 1 plus maximal common carotid intimal-medial thickness, maximal internal carotid intimal-medial thickness, and coronary artery calcification score

†

Cox Proportional Hazard ratios expressed per 1 standard deviation increment: 36 nmol/min/mL for activity, 42 ng/mL for mass.