Table 1.
Patient demographics and primary tumor characteristics stratified by nodal status (n=284)
| All patients | Node positive | Node negative | p- value† |
|
|---|---|---|---|---|
| n | 284 | 37 | 247 | |
| Age (years) | NS | |||
| Median (range) | 55 (12 – 84) | 55 (32 – 84) | 55 (12 – 82) | |
| Mean (STD) | 55.5 (14.3) | 55.1 (13.3) | 54.5 (14.4) | |
| Gender (n, %) | NS | |||
| Male | 151 (53.2) | 21 (56.8) | 130 (52.6) | |
| Female | 133 (46.8) | 16 (43.2) | 117 (47.4) | |
| Histologic type (n, %) | -- | |||
| Superficial spreading | 210 (73.9) | 24 (64.9) | 186 (75.3) | |
| Nodular | 26 (9.2) | 2 (5.4) | 24 (9.7) | |
| Acral lentiginous | 11 (3.9) | 2 (5.4) | 9 (3.6) | |
| Lentigo Maligna | 9 (3.2) | 2 (5.4) | 7 (2.8) | |
| Other | 6 (2.1) | 1 (2.7) | 5 (2.0) | |
| Not specified | 22 (7.7) | 6 (16.2) | 16 (6.5) | |
| Location (n, %) | NS | |||
| Head and Neck | 48 (16.9) | 9 (24.3) | 39 (15.8) | |
| Trunk | 105 (37.0) | 13 (35.1) | 92 (37.2) | |
| Extremities | 131 (46.1) | 15 (40.5) | 116 (47.0) | |
| Thickness (mm) | NS | |||
| Median (range) | 0.85 (0.3 – 1) | 0.85 (0.32 – 1) | 0.85 (0.3 – 1) | |
| Mean (STD) | 0.84 (0.13) | 0.81 (0.17) | 0.84 (0.13) | |
| Ulceration (n, %)$ | 17 (6.3) | 5 (14.3) | 12 (5.1) | 0.06a |
| Mitotic rate (n, %)$ | <0.05b | |||
| ≥1 mm2 | 116 (43.1) | 21 (63.6) | 95 (40.3) | |
| <1 mm2 | 153 (56.9) | 12 (36.4) | 141 (59.7) | |
| Clarks level (n, %)$ | NS | |||
| IV/V | 172 (61.0) | 20 (55.6) | 152 (61.8) | |
| ≤III | 110 (39.0) | 16 (44.4) | 94 (38.2) | |
| Regression (n, %)$ | 27 (10.0) | 3 (8.8) | 24 (10.1) | NS |
| VGP (n, %)$ | 167 (64.5) | 20 (66.7) | 147 (64.2) | NS |
| TIL (n, %)$ | NS | |||
| Brisk | 48 (31.6) | 10 (45.5) | 38 (29.2) | |
| Non-brisk | 60 (39.5) | 8 (36.4) | 52 (40) | |
| Absent | 44 (28.9) | 4 (18.2) | 40 (30.8) | |
For comparing between node positives and node negatives based on Wilcoxon, Chi-square or Fisher’s exact test.
Significant on chi-square and univariable logistic analysis for node positive vs. node negative (p<0.05) but not significant on multiple logistic regression analysis (p=0.06).
Significant on multiple logistic regression analysis for node positive vs. node negative.
Data unavailable or missing for ulceration in 13 cases, for mitotic rate in 15 cases, for Clarks level in 2 cases, for regression in 13 cases, for VGP in 25 cases and for TIL in 132 cases.
SLNB: sentinel lymph node biopsy, VGP: vertical growth phase, TIL: tumor infiltrating lymphocytes, NS: not significant.