Table 4.
Isolated papillary muscle data at 2.50 mM extracellular Ca2+ concentration
| Parameters | C (n = 10) | C-R (n = 13) | DM (n = 13) | DM-R (n = 12) |
|---|---|---|---|---|
| DT (g/mm2) | 5.83 ± 0.86 | 6.57 ± 2.02 | 7.00 ± 0.85 | 6.49 ± 0.66 |
| TPT (ms) | 148.23 ± 7.45 | 146.92 ± 8.07 | 195.12 ± 8.07* | 168.33 ± 14.39#§ |
| RT1/2 | 159.86 ± 29.59 | 169.76 ± 14.17 | 224.62 ± 5.27* | 213.43 ± 26.45# |
| +dT/dt (g/mm2/s) | 59.54 ± 9.53 | 72.65 ± 21.22 | 66.65 ± 7.71 | 69.07 ± 11.14 |
| −dT/dt (g/mm2/s) | 25.53 ± 4.75 | 26.93 ± 7.02 | 23.28 ± 4.25 | 21.98 ± 3.16 |
| CSA | 0.961 ± 0.194 | 0.962 ± 0.294 | 0.889 ± 0.140 | 0.951 ± 0.144 |
Data are expressed as mean ± standard deviation. One-way ANOVA in a factorial design 2 × 2 and Tukey’s post hoc test.
C untreated rats, C-R rutin-treated rats, DM untreated diabetic rats, DM-R rutin-treated diabetic rats, DT peak of developed tension, TPT time to peak of tension, RT 1/2 time from peak tension to 50% relaxation, +dT/dt maximum rate of tension development, −dT/dt maximum rate of tension decline, CSA papillary muscle cross-sectional area.
* p < 0.05 vs C; #p < 0.05 vs C-R; §p < 0.05 vs DM.