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. 2015 Jul 17;13:230. doi: 10.1186/s12967-015-0601-2

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© Massanella et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Characterization of CD57 expression in CD4 T cells. a The replicative senescence of the whole CD4 T-cell compartment was defined by the frequency of CD57⁺CD28⁻ cells. b In addition, the expression of CD57⁺ cells was evaluated in the different CD4 T cell subsets by analyzing the frequency of CD57⁺ cells. c The relationship between levels of spontaneous CD4 T-cell death and replicative immunosenescence is shown. Plots shows data from immunodiscordant (n = 23, red), low nadir immunoconcordant (n = 17, dark green) or high nadir immunoconcordant individuals (n = 16, light green) with color-coded linear regression for each data set. Linear regression for the global data is shown in black lines. Correlation coefficients and p values of Spearman’s test for the global analysis are shown. a, b also show data from HIV uninfected individuals (n = 11, blue bars).