Table 2.

Univariate and multivariate meta-regression analyses of potential source of heterogeneity

Heterogeneity factors	Serum S100β levels						Serum NSE levels
	Coefficient	SE	t	P	95 % CI		Coefficient	SE	t	P	95 % CI
					LL	UL					LL	UL
Publication year
Univariate	−0.078	0.114	−0.68	0.501	−0.313	0.157	0.189	0.068	2.78	0.016	0.042	0.335
Multivariate	−0.126	0.108	−1.17	0.529	−0.349	0.097	0.125	0.074	1.68	0.336	−0.040	0.290
Ethnicity
Univariate	−0.583	1.407	−0.41	0.682	−3.474	2.308	0.451	1.165	0.39	0.705	−2.067	2.968
Multivariate	−0.574	1.294	−0.44	0.983	−3.252	2.103	0.050	0.936	0.05	1.000	−2.035	2.136
Time
Univariate	−0.801	0.311	−2.58	0.016	−1.439	−0.163	−0.219	0.223	−0.98	0.344	−0.702	0.263
Multivariate	−0.896	0.327	−2.74	0.016	−1.571	−0.220	−0.086	0.178	−0.48	0.964	−0.483	0.312
Sample size
Univariate	0.647	0.866	0.75	0.462	−1.133	2.427	1.408	0.442	3.18	0.007	−0.452	2.364
Multivariate	0.649	0.792	0.82	0.807	−0.990	2.287	0.970	0.534	1.82	0.265	−0.220	2.161

SE Standard error. 95 % CI: 95 % confidence interval. NSE Neuron specific enolase. UL Upper limit. LL Lower limit