Table 1.
Characteristics of studies included in the current meta-analysis
| Surname | Year | Country | Ethnicity | Source | Genotype method | Case | Control | MAF | HWE | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| -819C>T (rs1800871) polymorphism | CC | CT | TT | All | CC | CT | TT | All | |||||||
| Lech-Maranda | 2004 | France | Caucasian | HB | PCR-RFLP | 107 | 81 | 11 | 199 | 53 | 46 | 13 | 112 | 0.321 | 0.536 |
| Guzowski | 2005 | USA | Caucasian | HB | DHPLC | 9 | 6 | 2 | 17 | 14 | 10 | 1 | 25 | 0.24 | 0.629 |
| Lan | 2006 | USA | Mixed | PB | TaqMan | 274 | 191 | 26 | 491 | 329 | 211 | 34 | 574 | 0.243 | 0.982 |
| Persico | 2006 | Italy | Caucasian | PB | PCR-RFLP | 138 | 100 | 12 | 250 | 53 | 51 | 6 | 110 | 0.286 | 0.159 |
| Wang | 2006 | USA | Mixed | PB | TaqMan | 625 | 427 | 92 | 1144 | 514 | 339 | 81 | 934 | 0.268 | 0.021 |
| Kube | 2007 | Germany | Caucasian | NA | NA | 230 | 167 | 21 | 418 | 111 | 81 | 10 | 202 | 0.25 | 0.325 |
| Lech-Maranda | 2007 | France | Caucasian | HB | PCR-RFLP | 92 | 68 | 15 | 175 | 53 | 46 | 13 | 112 | 0.321 | 0.536 |
| Purdue | 2007 | Australia | Caucasian | PB | TaqMan | 342 | 175 | 41 | 558 | 295 | 170 | 23 | 488 | 0.221 | 0.813 |
| Andrie | 2009 | Greece | Caucasian | HB | ARMS-PCR | 22 | 20 | 6 | 48 | 45 | 35 | 5 | 85 | 0.265 | 0.594 |
| Wong | 2010 | USA | Mixed | HB | TaqMan | 109 | 47 | 2 | 158 | 88 | 57 | 9 | 154 | 0.244 | 0.954 |
| Hosgood | 2013 | Asia | Asian | HB | TaqMan | 1193 | 971 | 237 | 2401 | 2033 | 1700 | 364 | 4097 | 0.296 | 0.749 |
| -592C>A (rs1800872) polymorphism | CC | AC | AA | All | CC | AC | AA | All | |||||||
| Lech-Maranda | 2004 | France | Caucasian | HB | PCR-RFLP | 107 | 81 | 11 | 199 | 53 | 46 | 13 | 112 | 0.321 | 0.536 |
| Guzowski | 2005 | USA | Caucasian | HB | DHPLC | 10 | 5 | 2 | 17 | 13 | 10 | 2 | 25 | 0.280 | 0.968 |
| Lan | 2006 | USA | Mixed | PB | TaqMan | 273 | 174 | 35 | 482 | 331 | 189 | 43 | 563 | 0.244 | 0.032 |
| Persico | 2006 | Italy | Caucasian | PB | PCR-RFLP | 138 | 100 | 12 | 250 | 53 | 51 | 6 | 110 | 0.286 | 0.159 |
| Wang | 2006 | USA | Mixed | PB | TaqMan | 601 | 426 | 93 | 1120 | 515 | 342 | 81 | 938 | 0.269 | 0.027 |
| Kube | 2007 | Germany | Caucasian | NA | NA | 226 | 165 | 21 | 412 | 111 | 81 | 10 | 202 | 0.250 | 0.325 |
| Lech-Maranda | 2007 | France | Caucasian | HB | PCR-RFLP | 92 | 68 | 15 | 175 | 53 | 46 | 13 | 112 | 0.321 | 0.536 |
| Purdue | 2007 | Australia | Caucasian | PB | TaqMan | 343 | 176 | 21 | 540 | 297 | 169 | 23 | 489 | 0.22 | 0.868 |
| Wong | 2010 | USA | Mixed | HB | TaqMan | 107 | 49 | 11 | 167 | 88 | 57 | 9 | 154 | 0.244 | 0.954 |
| Zhang | 2012 | China | Asian | HB | TaqMan | 226 | 228 | 60 | 514 | 269 | 235 | 53 | 557 | 0.306 | 0.872 |
| Hosgood | 2013 | Asia | Asian | HB | TaqMan | 1204 | 961 | 236 | 2401 | 2041 | 1685 | 362 | 4088 | 0.295 | 0.593 |
PB, Population based; HB, Hospital based; PCR-RFLP, polymorphism chain reaction-restriction fragment length polymorphism; DHPLC, denaturing high-performance liquid chromatography; MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium.