Table 2.
Meta-analysis of the association between IL10 polymorphisms and NHL risk
| Variables | No. of | Sample size Case/control |
Homozygous | Heterozygous | Recessive | Dominant | Allele comparing | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| studies | OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | ||
| -819C>T (rs1800871) | TT vs. CC | CT vs. CC | TT vs. (CT + CC) | (CT + TT) vs. CC | T vs. C | |||||||
| All | 11 | 5859/6893 | 0.97 (0.76-1.22) | 0.094 | 0.97 (0.90-1.04) | 0.821 | 1.04 (0.92-1.19) | 0.108 | 0.98 (0.91-1.05) | 0.558 | 0.99 (0.94-1.05) | 0.184 |
| Ethnicity | ||||||||||||
| Caucasian | 7 | 1665/1134 | 0.99 (0.63-1.55) | 0.118 | 0.90 (0.76-1.06) | 0.964 | 1.07 (0.79-1.46) | 0.132 | 0.92 (0.79-1.07) | 0.800 | 0.96 (0.85-1.09) | 0.365 |
| Asian | 1 | 2401/4097 | 1.10 (0.93-1.33) | / | 0.97 (0.88-1.08) | / | 1.12 (0.95-1.33) | / | 1.00 (0.90-1.10) | / | 1.02 (0.95-1.11) | / |
| Mixed | 3 | 1793/1662 | 0.80 (0.48-1.32) | 0.124 | 1.01 (0.88-1.17) | 0.190 | 0.86 (0.66-1.12) | 0.177 | 0.99 (0.86-1.13) | 0.086 | 0.97 (0.87-1.08) | 0.047 |
| Source of control | ||||||||||||
| PB | 4 | 2443/2106 | 1.02 (0.80-1.29) | 0.392 | 0.99 (0.87-1.12) | 0.430 | 1.02 (0.81-1.29) | 0.306 | 1.00 (0.88-1.12) | 0.603 | 1.00 (0.91-1.10) | 0.689 |
| HB | 6 | 2998/4585 | 0.80 (0.44-1.46) | 0.022 | 0.95 (0.86-1.05) | 0.712 | 1.05 (0.90-1.24) | 0.034 | 0.97 (0.88-1.06) | 0.244 | 0.99 (0.92-1.06) | 0.031 |
| Subtype | ||||||||||||
| DLBCL | 5 | 1997/6205 | 0.81 (0.66-0.99) | 0.510 | 1.02 (0.92-1.14) | 0.396 | 0.80 (0.65-0.98) | 0.535 | 0.99 (0.89-1.09) | 0.369 | 0.95 (0.88-1.03) | 0.374 |
| FL | 5 | 932/6205 | 1.00 (0.76-1.32) | 0.258 | 1.03 (0.88-1.20) | 0.223 | 1.00 (0.76-1.31) | 0.333 | 1.02 (0.89-1.19) | 0.161 | 1.02 (0.90-1.14) | 0.140 |
| -592C>A (rs1800872) | AA vs. CC | AC vs. CC | AA vs. (AC + CC) | (AC + AA) vs. CC | A vs. C | |||||||
| Alla | 11 | 6277/7350 | 1.04 (0.91-1.18) | 0.565 | 0.98 (0.92-1.06) | 0.652 | 1.04 (0.92-1.18) | 0.652 | 0.99 (0.93-1.06) | 0.542 | 1.00 (0.95-1.06) | 0.435 |
| Ethnicity | ||||||||||||
| Caucasian | 6 | 1593/1050 | 0.74 (0.52-1.04) | 0.743 | 0.89 (0.75-1.05) | 0.946 | 0.78 (0.55-1.09) | 0.739 | 0.87 (0.74-1.02) | 0.915 | 0.88 (0.77-1.00) | 0.824 |
| Asian | 2 | 2915/4645 | 1.14 (0.97-1.34) | 0.385 | 0.99 (0.90-1.10) | 0.206 | 1.14 (0.98-1.34) | 0.603 | 1.02 (0.93-1.12) | 0.169 | 1.04 (0.97-1.12) | 0.196 |
| Mixed | 3 | 1769/1655 | 0.99 (0.76-1.27) | 0.999 | 1.04 (0.90-1.20) | 0.235 | 0.97 (0.75-1.24) | 0.936 | 1.03 (0.90-1.18) | 0.329 | 1.01 (0.91-1.13) | 0.565 |
| Source of control | ||||||||||||
| PB | 4 | 2392/2100 | 0.94 (0.74-1.19) | 0.902 | 1.01 (0.89-1.15) | 0.366 | 0.93 (0.74-1.17) | 0.974 | 1.00 (0.89-1.12) | 0.367 | 0.99 (0.90-1.09) | 0.492 |
| HB | 6 | 3473/5048 | 1.08 (0.93-1.26) | 0.209 | 0.97 (0.88-1.06) | 0.508 | 1.09 (0.94-1.27) | 0.286 | 0.99 (0.91-1.08) | 0.336 | 1.01 (0.94-1.08) | 0.187 |
| Subtype | ||||||||||||
| DLBCL | 5 | 1986/6190 | 0.80 (0.66-0.99) | 0.510 | 1.02 (0.91-1.13) | 0.363 | 0.80 (0.66-0.97) | 0.498 | 0.98 (0.88-1.08) | 0.399 | 0.95 (0.87-1.03) | 0.448 |
| FL | 5 | 934/6190 | 1.08 (0.83-1.42) | 0.164 | 1.02 (0.88-1.19) | 0.375 | 1.08 (0.83-1.40) | 0.258 | 1.03 (0.89-1.19) | 0.199 | 1.03 (0.92-1.16) | 0.098 |
HB, Hospital based; PB, Population based; DLBCL, Diffuse large B-cell lymphomas; FL, Follicular lymphoma.