Table 2. Statin use and lipid levels over the course of the study.
| On statin (study or non-study) n (%) |
Total cholesterol mean (SD) n |
HDL cholesterol mean (SD) n |
LDL cholesterol mean (SD) n |
Triglycerides mean (SD) n |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GFR group (ml/min per 1.73 m2) | Pravastatin | Usual care | Pravastatin | Usual care | Pravastatin | Usual care | Pravastatin | Usual care | Pravastatin | Usual care |
| Total | ||||||||||
| Baseline | 5,085 (100) | 0 (0)** | 223.6 (26.9) 5,068 |
223.6 (26.6) 5,056 |
47.5 (13.4) 5,068 |
47.4 (13.5) 5,055 |
145.5 (21.3) 5,063 |
145.4 (21.3) 5,052 |
150.6 (70.3) 4,431 |
153.0 (73.1) 4,439 |
| Year 2 | 4,069 (89.8) | 365 (8.2)** | 187.2 (34.7) 3,676 |
213.8 (34.3)** 3,366 |
48.9 (14.1) 670 |
47.3 (15.0) 386 |
109.7 (30.3) 647 |
134.6 (30.0)** 369 |
149.8 (90.8) 498 |
156.8 (87.9) 298 |
| Year 4 | 3,055 (86.4) | 566 (16.3)** | 183.8 (35.1) 2,699 |
205.8 (36.8)** 2,553 |
49.5 (14.3) 454 |
45.2 (12.3)** 300 |
103.9 (27.6) 437 |
128.1 (32.2)** 284 |
142.6 (80.6) 327 |
174.9 (155.9)* 206 |
| Year 6 | 943 (87.0) | 245 (23.5)** | 176.2 (32.9) 829 |
196.6 (37.1)** 776 |
47.5 (14.3) 130` |
44.5 (15.1) 66 |
103.1 (28.7) 128 |
121.4 (35.8)** 64 |
135.3 (70.6) 85 |
137.5 (56.6) 44 |
| % Δ Baseline to Year 6 | –20.7 (13.3) 824 |
–11.2 (15.7)** 771 |
+1.5 (22.4) 130 |
+3.5 (21.6) 65 |
–30.2 (19.9) 127 |
–15.1 (24.9)** 63 |
+3.9 (54.1) 81 |
–5.9 (30.9) 39 |
||
| GFR (≥ 60) | ||||||||||
| Baseline | 4,302 (100) | 0 (0)** | 223.1 (27.0) 4,287 |
223.6 (26.3) 4,278 |
47.7 (13.3) 4,287 |
47.5 (13.4) 4,277 |
145.4 (21.4) 4,284 |
145.6 (21.3) 4,276 |
148.2 (69.3) 3,768 |
151.1 (69.3) 3,777 |
| Year 2 | 3,474 (90.3) | 312 (8.2)** | 187.7 (34.9) 3,140 |
214.4 (34.5)** 2,866 |
48.8 (13.6) 579 |
47.6 (15.5) 325 |
110.7 (30.6) 562 |
135.0 (30.4)** 310 |
149.2 (90.2) 429 |
153.0 (86.7) 251 |
| Year 4 | 2,623 (86.8) | 496 (16.7)** | 184.3 (35.3) 2,324 |
205.7 (36.4)** 2,179 |
49.8 (14.2) 385 |
44.7 (12.3)** 262 |
105.1 (27.4) 373 |
128.6 (32.1)** 246 |
138.7 (76.3) 282 |
181.8 (164.1)** 181 |
| Year 6 | 792 (87.9) | 212 (24.0)** | 176.5 (33.4) 693 |
196.7 (38.0)** 670 |
46.5 (12.6) 113 |
45.3 (15.8) 58 |
104.1 (29.7) 111 |
119.7 (35.1)* 57 |
136.3 (71.5) 76 |
133.3 (53.1) 38 |
| % Δ Baseline to Year 6 | –20.3 (13.2) 688 |
–11.0 (15.9)** 666 |
+0.4 (20.5) 113 |
+4.1 (22.7) 57 |
–29.1 (20.3) 110 |
–16.3 (23.4)** 56 |
+4.8 (56.1) 73 |
–3.1 (31.4) 34 |
||
| GFR (< 60) | ||||||||||
| Baseline | 783 (100) | 0 (0)** | 226.1 (26.2) 781 |
223.7 (28.3) 778 |
46.6 (13.8) 781 |
46.6 (14.1) 778 |
146.5 (21.1) 779 |
144.4 (21.4) 776 |
164.5 (74.3) 663 |
164.1 (91.0) 662 |
| Year 2 | 595 (87.1) | 53 (7.9)** | 184.6 (33.8) 536 |
210.5 (33.0)** 500 |
49.5 (16.9) 91 |
46.0 (12.1) 61 |
102.7 (27.2) 85 |
132.2 (27.2)** 59 |
153.8 (94.7) 69 |
176.6 (92.5) 47 |
| Year 4 | 432 (83.9) | 70 (13.8)** | 180.4 (33.5) 375 |
206.3 (39.4)** 374 |
47.9 (15.0) 69 |
48.4 (12.6) 38 |
97.0 (28.0) 64 |
124.7 (33.1)** 38 |
167.2 (101.2) 45 |
124.9 (51.4) 25 |
| Year 6 | 151 (82.5) | 33 (21.2)** | 174.4 (30.5) 136 |
196.0 (31.2)** 106 |
54.4 (21.8) 17 |
38.1 (5.7) 8 |
96.5 (21.3) 17 |
135.0 (41.2)* 7 |
126.8 (65.4) 9 |
164.2 (75.3) 6 |
| % Δ Baseline to Year 6 | –22.9 (13.3) 136 |
–12.4 (14.5)** 105 |
+8.9 (32.1) 17 |
–1.2 (10.0) 8 |
–37.2 (15.4) 17 |
–5.3 (35.7)* 7 |
–4.5 (30.8) 8 |
–24.3 (21.5) 5 |
||
Comparison between treatment groups: *p < 0.05; **p < 0.001. GFR = glomerular filtration rate.