Table 3.

Comparison of screening algorithms for pulmonary hypertension in systemic sclerosis

Approach	False negatives, % (missed diagnoses)	Sensitivity, %	Specificity, %	PPV, %	NPV, %
SDE at rest and during exercise	1	96	82	68	98
N = 76
DETECT algorithm	4	96	48	35	98
N = 319
DETECT algorithm with	15	85	72	47	94
65 % specificity at step 2
N = 319
DETECT data with algorithm from
ESC/ERS guidelines*	29	71	69	40	89
N = 371

PPV positive predictive value (confirmed pulmonary arterial hypertension out of all right heart catheterization referrals), NPV negative predictive value, SDE stress Doppler echocardiography, ESC/ERS European Society of Cardiology/European Respiratory Society

Adaptation of the table provided by Coghlan et al. [11] in the DETECT study

*Evaluated on a subset of patients from DETECT study (n = 371) with available data for the variables defined in the guideline

Criteria were the following: (a) tricuspid regurgitant jet velocity >3.4 m/s or (b) tricuspid regurgitant jet velocity >2.8 to ≤ 3.4 m/s AND symptomatic (defined as at least one of the following DETECT parameters: current anginal pain, current syncope/near syncope, current dyspnoea, or presence of peripheral oedema) or (c) tricuspid regurgitant jet velocity ≤2.8 m/s AND symptomatic (defined as above) AND presence of additional echocardiography variables suggestive of pulmonary hypertension (defined as right atrium area >16 cm² or ratio of right ventricular diameter/left ventricular end diastolic diameter >0.8 or both)