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. 2015 May 7;13:146. doi: 10.1186/s12967-015-0511-3

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© Bauerschlag et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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¹⁸ F-FCH uptake as a percentage of the administered activity normalized to protein content. ¹⁸ F-FCH uptake as a percentage of the administered activity normalized to protein content in the Hey (a) and cisplatin-resistant Hey_cis (b) cell lines. Cisplatin-resistant Hey_cis cells demonstrated lower mean ¹⁸ F-FCH uptake compared to parental Hey cells (5.42% ± 0.23% vs. 3.79% ± 0.14% of administered activity). At 2.5 μmol/L cisplatin, both tested cerulenin concentrations decreased ¹⁸ F-FCH uptake in cisplatin-resistant Hey_cis cells. For the parental Hey cells, this effect was only detectable at the higher cerulenin concentration. Treatment with cerulenin alone did not affect the cellular uptake of ¹⁸ F-FCH in any tested cell line. cis = cisplatin; cer = cerulenin.