Table 2.
Odds ratio (95%CI) and p-values† for significant* IKZF1 SNPs associated with childhood ALL risk in the Hispanic population, CCLS, 1995-2008
| Chr. | SNP | Minor Allele (frequency) | Base-pair location | ORa | 95% CI | Pvalues | Pvaluesb |
|---|---|---|---|---|---|---|---|
| 7 | rs7780012 | A (0.12) | 50438720 | 0.50 | 0.35, 0.71 | 0.00013 | 0.004426 |
| 7 | rs11980379 | G (0.28) | 50469981 | 1.47 | 1.17, 1.85 | 0.00093 | 0.01054 |
| 7 | rs4132601 | C (0.28) | 50470604 | 1.47 | 1.17, 1.85 | 0.00093 | 0.01054 |
| 7 | rs716719 | A (0.46) | 50325717 | 1.38 | 1.12, 1.69 | 0.002102 | 0.01787 |
| 7 | rs6952409 | A (0.23) | 50462935 | 1.41 | 1.11, 1.78 | 0.004368 | 0.0297 |
| 7 | rs6964823 | A (0.31) | 50460096 | 0.73 | 0.59, 0.91 | 0.00585 | 0.03315 |
| 7 | rs7781977 | G (0.49) | 50346134 | 0.75 | 0.61, 0.93 | 0.007108 | 0.03452 |
| 7 | rs9886239 | A (0.48) | 50336551 | 0.76 | 0.62, 0.93 | 0.008676 | 0.03531 |
| 7 | rs4917017 | G (0.49) | 50335232 | 0.76 | 0.62, 0.94 | 0.009347 | 0.03531 |
| 7 | rs12719019 | A (0.28) | 50476139 | 0.75 | 0.60, 0.95 | 0.01467 | 0.04988 |
a
Odds ratio (OR) and 95% confidence interval (CI) calculated using log additive models adjusting for age, sex and top 5 genetic principal components (PCs).
b
P-values based on correlation for False Discovery Rate (FDR) using Benjamini and Hochberg (BH) procedure.
†
Adjusted and unadjusted for multiple comparisons.
*
Ten of thirty-four SNPs had significant p-values adjusted for FDR.