Table 3.
Odds ratio (95% CI) and p-values† for significant* ARID5B SNPs associated with childhood ALL risk in the Hispanic population, CCLS, 1995-2008
| Chr. | SNP | Minor Allele (frequency) | Base-pair location | ORa | 95% CI | Pvalues | Pvaluesb |
|---|---|---|---|---|---|---|---|
| 10 | rs7089424 | C (0.49) | 63752159 | 2.12 | 1.70, 2.65 | 2.04E-11 | 1.16E-09 |
| 10 | rs7090445 | G (0.49) | 63721176 | 2.08 | 1.67, 2.60 | 6.24E-11 | 1.57E-09 |
| 10 | rs4506592 | G (0.49) | 63727187 | 0.48 | 0.38, 0.60 | 8.24E-11 | 1.57E-09 |
| 10 | rs7073837 | C (0.48) | 63699895 | 0.55 | 0.45, 0.69 | 6.84E-08 | 9.75E-07 |
| 10 | rs10821938 | C (0.45) | 63724773 | 0.56 | 0.45, 0.69 | 1.24E-07 | 1.42E-06 |
| 10 | rs10994981 | A (0.41) | 63708007 | 0.65 | 0.52, 0.80 | 7.94E-05 | 0.000754 |
| 10 | rs6479778 | A (0.29) | 63689077 | 1.52 | 1.21, 1.90 | 0.000326 | 0.002651 |
| 10 | rs2893881 | G (0.30) | 63688672 | 1.47 | 1.18, 1.84 | 0.000759 | 0.005406 |
| 10 | rs4948491 | G (0.46) | 63696889 | 1.43 | 1.16, 1.76 | 0.000941 | 0.005514 |
| 10 | rs4948488 | G (0.40) | 63685154 | 1.44 | 1.16, 1.79 | 0.000967 | 0.005514 |
| 10 | rs12249208 | A (0.03) | 63730012 | 0.36 | 0.18, 0.72 | 0.003687 | 0.01911 |
a
Odds ratio (OR) and 95% confidence interval (CI) calculated using log additive models adjusting for age, sex and top 5 genetic principal components (PCs).
b
P-values based on correlation for False Discovery Rate (FDR) using Benjamini and Hochberg (BH) procedure.
†
Adjusted and unadjusted for multiple comparisons.
*
Eleven of fifty-seven SNPs had significant p-values adjusted for FDR.