TABLE 3—
Estimated Regression Parameters and 95% Confidence Intervals: British National Child Development Study, 1981, 1991, 2000, and 2002–2004
| Class | Fibrinogen, b (95% CI) | CRP, b (95% CI) | VWF, b (95% CI) | TPA, b (95% CI) | Ddimer, b (95% CI) | Metabolic Syndrome, OR (95% CI) | FVC, b (95% CI) |
| Men | |||||||
| 1 (Ref) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 |
| 2 | 0.020 (−0.006, 0.045) | 0.128 (−0.009, 0.265) | 0.029 (−0.010, 0.069) | 0.036 (−0.029, 0.100) | 0.035 (−0.035, 0.106) | 0.754 (0.575, 0.988) | 0.077 (−0.020, 0.175) |
| 3 | 0.008 (−0.016, 0.032) | −0.022 (−0.169, 0.125) | −0.004 (−0.048, 0.041) | 0.022 (−0.045, 0.089) | 0.041 (−0.031, 0.112) | 1.075 (0.815, 1.417) | −0.103 (−0.206, −0.001) |
| 4 | 0.008 (−0.015, 0.031) | 0.007 (−0.113, 0.128) | 0.003 (−0.036, 0.041) | 0.003 (−0.054, 0.059) | 0.054 (−0.014, 0.123) | 1.077 (0.843, 1.376) | −0.080 (−0.172, 0.013) |
| 5 | 0.031 (−0.019, 0.082) | 0.080 (−0.210, 0.369) | 0.012 (−0.064, 0.088) | 0.061 (−0.066, 0.189) | 0.030 (−0.109, 0.169) | 0.666 (0.385, 1.152) | 0.020 (−0.165, 0.204) |
| 6 | 0.034 (0.011, 0.056) | 0.147 (0.024, 0.270) | 0.020 (−0.016, 0.057) | 0.061 (0.006, 0.116) | 0.039 (−0.029, 0.106) | 0.881 (0.690, 1.124) | −0.132 (−0.227, −0.037) |
| Women | |||||||
| 1 (Ref) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 |
| 2 | −0.018 (−0.034, −0.001) | −0.085 (−0.184, 0.013) | −0.010 (−0.038, 0.017) | −0.035 (−0.080, 0.010) | −0.003 (−0.048, 0.043) | 1.011 (0.813, 1.256) | 0.056 (0.002, 0.110) |
| 3 | −0.011 (−0.036, 0.015) | −0.010 (−0.157, 0.136) | −0.002 (−0.045, 0.041) | 0.009 (−0.059, 0.078) | −0.065 (−0.130, 0.001) | 0.764 (0.551, 1.059) | 0.033 (−0.042, 0.108) |
| 4 | 0.010 (−0.018, 0.039) | 0.198 (0.033, 0.364) | 0.039 (−0.008, 0.085) | −0.026 (−0.110, 0.059) | −0.037 (−0.105, 0.031) | 1.075 (0.742, 1.560) | −0.002 (−0.101, 0.096) |
| 5 | −0.001 (−0.023, 0.023) | −0.033 (−0.175, 0.109) | −0.011 (−0.042, 0.029) | −0.008 (−0.072, 0.056) | 0.023 (−0.040, 0.085) | 0.694 (0.496, 0.972) | 0.022 (−0.051, 0.095) |
| 6 | 0.028 (0.006, 0.050) | 0.031 (−0.103, 0.165) | 0.023 (−0.013, 0.060) | −0.031 (−0.089, 0.028) | −0.014 (−0.073, 0.045) | 0.773 (0.580, 1.030) | −0.055 (−0.121, 0.010) |
Note. CI = confidence interval; CRP = C-reactive protein; Ddimer = fibrin d-dimer; FVC = forced vital capacity; OR = odds ratio; TPA = tissue plasminogen activator antigen; VWF = von Willebrand factor. Estimates were adjusted for serious early-life socioeconomic position (latent summary of financial hardship during the past year at age 11 years, access to household amenities at age 11 years, paternal social class at age 7 years, number of people per room at birth, housing tenure at age 7 years, and paternal weekly net pay at age 16 years), health center attendance during the past year at age 16 years, disability at age 16 years, height at age 7 years, cognitive ability at age 11 years, educational attainment at age 23 years, social class at age 23 years, housing tenure at age 23 years, net family income at age 23 years, self-rated health at age 23 years, depression at age 23 years, employment status at age 23 years, body mass index at age 23 years, presence of long-standing disability at age 23 years, current use of medication at age 42 years, and lab processing–related variables. All outcomes modeled with linear regression (with effect estimate reported as linear regression coefficient −b), except for metabolic syndrome for which logistic regression was used (with effect estimate reported as an OR).