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. 2015 Jul 17;13:234. doi: 10.1186/s12967-015-0543-8

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© Jiang et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Primitive hematopoietic cells showed an earlier regeneration than leukemic cells post therapy. a Representative flow cytometry plots of leukemic cells in the BM of the 1-day treated leukemic mice on the therapeutic day (d0), and on the 1st, 2nd, 5th, and 12th day post therapy. b Representative flow cytometry plots of CD45.2⁺LK⁺S⁺ and CD45.2⁺LK⁺S⁻ cells in the BM of normal control (shown as N) and the 1-day treated leukemic mice post therapy. Cells were gated in CD45.2⁺Lin⁻ populations. c Frequencies of leukemic cells in whole MNCs and CD45.2⁺LK⁺S⁻ and CD45.2⁺LK⁺S⁺ cells in CD45.2⁺ hematopoietic cell fractions in the BM of the 1-day treated leukemic mice on the therapeutic day (d0) and following days (n = 3–4). d Total numbers of leukemic cells, CD45.2⁺LK⁺S⁻ and CD45.2⁺LK⁺S⁺ cells in the BM (double hindlimbs) of the 1-day treated leukemic mice on different time (n = 3–4). e Frequencies of CMP, GMP, and MEP in CD45.2⁺LK⁺S⁻ cells in the BM of normal control and the 1-day treated leukemic mice on different time (n = 3–8). f Frequencies of LT-HSC, ST-HSC, and MPP in CD45.2⁺LK⁺S⁺ cells in the BM of normal control and the 1-day treated leukemic mice on different time (n = 3–9). g–j Total numbers of LT-HSC, ST-HSC, MPP, and CD45.2⁺LK⁺S⁺ cells of the leukemia-only control and the 1-day treated leukemic mice in BM (double hindlimbs) on different days (n = 3–6). k–n Frequencies of LT-HSC, ST-HSC, MPP and CD45.2⁺LK⁺S⁺ cells in CD45.2⁺ hematopoietic cell fractions in the BM of the leukemia-only control and the 1-day treated leukemic mice on different days (n = 3–6). All data were presented as mean ± SEM. Statistical significance determined as: *p < 0.05; **p < 0.01; ***p < 0.001.