Table 2.

Association of symptom cluster (arthralgia, fatigue, and insomnia) with inflammatory biomarkers

	Univariate analysis		Multivariate analysis
	Coefficient (95 % CI)	p value	Coefficient (95 % CI)	p value
CRP	117.3 (49.3–185.3)	0.001	93.1 (25.1–161.1)	0.008
Eotaxin	87.3 (40.8–133.7)	<0.001	79.9 (32.5–127.2)	0.001
MCP-1	178 (63–293.2)	0.003	151.2 (32.7–269.8)	0.013
VDBP	21,530.8 (8088.4–34,973.2)	0.002	19,422 (5500.5–33,344)	0.006

Data shown are results of multivariate linear regression analyses controlled for race, body mass index, chemotherapy status, non-steroidal anti-inflammatory drug use, and age

CI confidence interval, CRP C-reactive protein, MCP-1 monocyte chemoattractant protein 1, VDBP vitamin D–binding protein