Table 3. Correlations between the liver iron concentration determined by MRI and iron biomarkers in 212 hemodialysis patients studied (Spearman rank order correlation test).
Overall Cohort (n°1+n°2)(212 patients) | Cohort n°1 of 119 patients | Cohort n°2 of 93 patients | ||||
---|---|---|---|---|---|---|
Parameter | Spearman rho [95% confidence interval] | P values at test | Spearman rho [95% confidence interval] | P values at test | Spearman rho [95% confidence interval] | P values at test |
Serum Ferritin (microg/L) | 0.52 [0.41 to 0.61] | p< 0.0001 | 0.52 [0.37 to 0.65] | p< 0.0001 | 0.47 [0.29 to 0.62] | p< 0.0001 |
serum iron (micromol/L) | 0.22 [0.09 to 0.35] | p = 0.0011 | 0.26 [0.07 to 0.42] | p = 0.0048 | 0.26 [0.05 to 0.44] | p = 0.0128 |
Serum Transferrin (g/L) | - 0.34 [-0.46 to -0.21] | p< 0.0001 | -0.24 [-0.41 to -0.05] | p = 0.0131 | -0.35 [-0.52 to -0.15] | p = 0.0006 |
Serum solubleTransferrin receptors (sTfR) (mg/L) | - 0.12 [-0.27 to 0.02] | p = 0.0868 | -0.07 [-0.27 to 0.14] | p = 0.5249 | -0.11 [-0.31 to 0.11] | p = 0.3128 |
TSAT (%) | 0.36 [0.24 to 0.48] | p< 0.0001 | 0.37 [0.20 to 0.52] | p< 0.0001 | 0.36 [0.16 to 0.53] | p = 0.0004 |
sTfR/Ferritin ratio | - 0.43 [-0.54 to -0.30] | p< 0.0001 | -0.44 [-0.59 to -0.26] | p< 0.0001 | -0.36 [-0.53 to −0.16] | p = 0.0004 |
Hepcidin (ng/mL) | 0.42 [0.29 to 0.54] | p< 0.0001 | 0.34 [0.14 to 0.51] | p = 0.0008 | 0.42 [0.23 to 0.58] | p< 0.0001 |
Erythrocyte mean corpuscular volume (fL) | 0.04 [-0.10 to 0.18] | p = 0.5637 | 0.002 [-0.18 to 0.19] | p = 0.99 | 0.14 [-0.07 to 0.34] | p = 0.1774 |
Data are given as area of the Spearman rho with the [95% confidence interval].