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. 2015 Jul 16;11(7):e1004303. doi: 10.1371/journal.pcbi.1004303

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© 2015 Neale et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — (A) Backbone trace of TmCorA viewed along the pore axis from the extracellular side, colored by protomer. Divalent cations in the 2HN2 crystal structure [13] are shown as spheres for (green) regulatory cations and (blue) cations inside the pore. (B) Side view of two protomers. Annotations include cation binding sites in the cytoplasmic domain and the upper and lower regions of the pore (respectively DCS, UBS, and LBS) and the transmembrane region (TM). (C) Surface representation of the pore diameter in the 2HN2 crystal structure [13]. The lower leucine constriction (LC) is indicated. The pore is colored by its local diameter, which is either (blue) larger than that of hexahydrated magnesium (0.68 nm), (red) smaller than that of a single water molecule (0.28 nm), or (grey) intermediate.