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. 2015 Jul 16;11(7):e1004303. doi: 10.1371/journal.pcbi.1004303

Fig 10. Enhanced MM wetting resulting from pore-widening mutation L294A.

Fig 10

(A-C) Ensemble averages of the number of water molecules in the MM, N wat, as functions of time, t, for (solid red) wild type, WT, and (broken blue) L294A simulations (A,B) without and (C) with regulatory ions in the DCS. Shaded regions enclose the standard deviation among 200 repeat simulations. Initial conformations had N wat values of (A) 42 or (B, C) 25. (D) Increase in hydration due to the L294A mutation, ΔN wat = N wat(L294A)—N wat(WT), as a function of t (black solid line) without regulatory ions, initial N wat = 42; (red broken line) without regulatory ions, initial N wat = 25; and (blue dotted line) with regulatory ions, initial N wat = 25.