Fig 3. Total distribution of “first of choice” glaucoma medication in Denmark in the period from 1996 to 2011.

The distribution of “first of choice” medication is shown throughout the study period. The use of β-blockers has decreased (p < 0.001), whereas the use of prostaglandin analogs and combination drugs has increased in the studied period (p < 0.001). The lower figure shows the time line of the introduction of glaucoma medication (modified from European Guidelines, 4^th edition). Abreviations: β-block., β-blockers; Prostagl., prostaglandin analogs; α-adren., α2-adrenergic agonists; Paras., parasympathomimetic drugs; CAI, carbon anhydrase inhibitors; Comb., combination drugs.