Fig 3. FoxP3+ regulatory T cells are increased in high compared to low transmission settings, but decrease with age only in highly exposed children.

(A) FoxP3+CD25+CD127^dim regulatory T cell frequencies in children age 1 to 11 years (PRISM cohort) residing in the low transmission Jinja District (n = 34) were compared to children in the high transmission Tororo District (n = 91). Wilcoxon ranksum p value indicated. (B) FoxP3+CD25+CD127^dim regulatory T cell frequencies were compared between children from low and high transmission areas at age 1–4 (n = 11 and n = 18), 4–7 (n = 14 and n = 35) and 7–11 (n = 9 and n = 38) years of age and adults (n = 9 and n = 37). Wilcoxon ranksum for age group comparisons, p values indicated.