FIGURE 1.

Study design. From a cohort of children with cochlear implants (CIs), 12 with poor CI outcomes were selected as “cases” and 30 with good CI outcomes were selected as “matched controls.” These 42 children were subjected to comprehensive genetic analyses using massively parallel sequencing, which targeted 129 known deafness genes. Genotypes were then compared between “cases” and “matched controls,” and phenotypes were correlated to the genetic diagnoses. CAP, Categories of Auditory Performance; MPS, massively parallel sequencing; SIR, Speech Intelligibility Rating.