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. Author manuscript; available in PMC: 2015 Jul 16.
Published in final edited form as: Biomacromolecules. 2014 Jul 2;15(7):2725–2734. doi: 10.1021/bm500588x

Figure 6.

Figure 6

Both unmodified and mannan-modified P(HEMA-co-MAA) nanogels were internalized effectively by macrophages but higher internalization rates were observed for MN-modified nanogels. (A) Chemical attachment of amine-containing fluorescent dye CF 488A (green) to the surface of P(HEMA-co-MAA) nanogels allow for imaging using confocal microscopy. Cell membrane (red) and nucleus (blue) were stained after 2 h of incubation of cells with the unmodified or mannan-modified nanogels. (B) Percentage of cells internalizing unmodified or mannan-modified nanogels. (C) Average number of unmodified or mannan-modified nanogels per cell. Data are expressed as the mean ± SEM of three independent experiments. Different letters indicate statistically significant differences between the groups at p < 0.05.