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Simulation 1: (a) ROC curves for identification of differential gene expression under the proposed method, edgeR, Bayseq, DEGseq and the overdispersed logistic regression model. (b) ROC curves under the proposed method but with fixed ξ̅k and position-level read counts normalized with the TMM method (dotted line), the proposed method (solid line) and edgeR(dashed line).
