Table 3.
Baseline Demographics
| Variable | Normal (n=13) |
Non-severe Asthma (n=7) |
Severe Asthma (n=9) |
All Groups (n=29) |
p-value1 | |
|---|---|---|---|---|---|---|
| Age at Enrollment (years) | 24.9 ± 6.8 | 30.4 ± 14.8 | 45.9 ± 7.6 | 32.7 ± 13.0 | <0.0012 | |
| BMI (kg/m2) | 26.4 ± 6.0 | 27.0 ± 5.0 | 31.3 ± 5.8 | 28.0 ± 5.9 | 0.14 | |
| Duration of Asthma (years) | n/a | 18.2 ± 14.2 | 22.1 ± 15.6 | 20.4 ± 15.2 | 0.63 | |
| Race | White, % (n) | 46.2 (6) | 100.0 (7) | 77.8 (7) | 69.0 (20) | 0.13 |
| Black, % (n) | 38.5 (5) | 0 | 22.2 (2) | 24.1 (7) | ||
| Other, % (n) | 15.4 (2) | 0 | 0 | 6.9 (2) | ||
| Gender | Male, % (n) | 61.5 (8) | 71.4 (5) | 66.7 (6) | 65.5 (19) | 1.00 |
| Female, % (n) | 38.5 (5) | 28.6 (2) | 33.3 (3) | 34.5 (10) | ||
| FEV1, L,(% predicted) | Pre-BD | 3.97 ± 0.66 (102.6 ± 9.4) |
4.17 ± 1.04 (99.9 ± 12.3) |
2.20 ± 0.57 (64.5 ± 17.1) |
3.47 ± 1.13 (90.1 ± 21.4) |
<0.0013 (<0.001 4) |
| Post-BD | 4.15 ± 0.71 (106.5 ± 9.9) |
4.57 ± 1.06 (109.3 ± 11.0) |
2.43 ± 0.63 (71.2 ± 18.0) |
3.71 ± 1.17 (96.2 ± 21.3) |
<0.0015 (<0.001 6) |
|
Comparison among all groups using analysis of variance for continuous measures or Fisher’s exact test for categorical measures
Uncorrected pairwise comparisons: Non-severe vs. Normal p=0.22, Severe vs. Normal p=<0.0001, Non-severe vs. Severe p= 0.003.
Pairwise comparison using Tukey’s correction: Non-severe vs. Normal p=0.84, Severe vs. Normal p=<0.0001, Non-severe vs. Severe p <0.001.
Pairwise comparison using Tukey’s correction: Non-severe vs. Normal p=0.89, Severe vs. Normal p=<0.0001, Non-severe vs. Severe p <0.001.
Pairwise comparison using Tukey’s correction: Non-severe vs. Normal p=0.49, Severe vs. Normal p=<0.0001, Non-severe vs. Severe p <0.001.
Pairwise comparison using Tukey’s correction: Non-severe vs. Normal p=0.89, Severe vs. Normal p=<0.0001, Non-severe vs. Severe p <0.001.