Table 2.
Physiologic and laboratory parameters
| Characteristics | Sham (n=6) | Severe Shock (n=6) | LR Resuscitation (n=6) | LR+RSV Resuscitation (n=6) |
|---|---|---|---|---|
| MAP (mmHg) | 111 ± 2 | 41 ± 1a | 78 ± 5a,b | 86 ± 2a,b |
| HR (bpm) | 440 ± 12 | 419 ± 8a | 438 ± 23 | 456 ± 15 |
| Lactate (mmol/L) | 1.3 ± 0.3 | 17.2 ± 1.3a | 10.2 ± 1.2a,b | 6.9 ± 1.3b,c |
| pH | 7.40 ± 0.01 | 7.05 ± 0.09a | 7.20 ± 0.04a,b | 7.32 ± 0.03b |
| PCO2 (mmHg) | 47 ± 4 | 17 ± 2a | 28 ± 1a,b | 33 ± 1b |
| PO2 (mmHg) | 85 ± 4 | 128 ± 4a | 113 ± 5a | 105 ± 2b |
| HCO3− (mmol/L) | 29.1 ± 2.0 | 5.4 ± 1.6a | 11.3 ± 1.1a,b | 17.2 ± 1.4b,c |
| BUN (mg/dl) | 23 ± 2 | 29 ± 2a | 25 ± 1 | 30 ± 3 |
| Creatinine (mg/dl) | 0.28 ± 0.03 | 0.63 ± 0.03a | 0.53 ± 0.05a | 0.57 ± 0.06a |
| Na+ (mmol/L) | 135 ± 1 | 128 ± 1a | 130 ± 3 | 138 ± 1b,c |
| K+ (mmol/L) | 4.5 ± 0.3 | 6.4 ± 0.6a | 5.0 ± 0.4b | 5.4 ± 0.4b |
| Cl− (mmol/L) | 103 ± 1 | 101 ± 1a | 100 ± 2 | 112 ± 3b,c |
| Hemoglobin (g/L) | 12.3 ± 0.4 | 5.0 ± 0.5a | 3.8 ± 0.1b | 4.1 ± 0.3 |
| NGAL (ng/ml) | 60.5 ± 8.2 | 73 ± 23.2 | 107.8 ± 28.5 a,b | 53.6 ± 1.0 b,c |
LR = Lactated Ringer’s solution; RSV = Resveratrol; MAP = Mean Blood Pressure; HR = Heart Rate; NGAL = Neutrophil gelatinase-associated lipocalin; BUN = Blood Urea Nitrogen. Values are mean ± SEM. n = 6.
a
p<0.05 versus Sham.
b
p<0.05 versus Severe Shock.
c
p<0.05 versus LR Resuscitation.